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Table 2 Univariate analysis of the relationship between Helicobacter pylori virulence genotypes and clinical outcome according to country, from patients presenting peptic ulcer disease or non-ulcer dyspepsia.

From: Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA

 

Prevalence (%) PUD vs NUD

p-value; OR [95%CI]

 

homB

homA

cagA

vac A s1

babA

Portugal

50 PUD; 50 NUD

59.6 vs 56.0

N.S.

40.4 vs 44.0

N.S.

72.3 vs 40.0

0.002; 1.88 [1.26–2.81]

63.8 vs 44.0

N.S.

48.9 vs 32.0

N.S.

France

27 PUD; 6 NUD

74.1 vs 28.6

N.S.

37.0 vs 71.4

N.S.

85.2 vs 60.0

N.S.

85.2 vs 80.0

N.S.

80.0 vs 50.0

N.S.

Sweden

12 PUD; 10 NUD

41.7 vs 30.0

N.S.

58.3 vs 70

N.S.

83.3 vs 70.0

N.S.

66.7 vs 70.0

N.S.

83.3 vs 40.0

N.S.

Germany

9 PUD; 10 NUD

55.6 vs 60.0

N.S.

44.4 vs 40.0

N.S.

100 vs 80

N.S.

100 vs 80.0

N.S.

77.8 vs 60.0

N.S.

USA

10 PUD; 13 NUD

40.0 vs 33.3

N.S.

60.0 vs 66.7

N.S.

60.0 vs 91.7

N.S.

70.0 vs 91.7

N.S.

100 vs 91.7

N.S.

Brazil

10 PUD; 12 NUD

70.0 vs 27.3

N.S.

30.0 vs 72.7

N.S.

60 vs 18.2

N.S.

50.0 vs 27.3

N.S.

100 vs 100

N.S.

Colombia

9 PUD; 9 NUD

77.8 vs 60.0

N.S.

33.3 vs 50.0

N.S.

55.6 vs 80

N.S.

66.7 vs 70.0

N.S.

100 vs 70.0

N.S.

Japan

42 PUD; 28 NUD

95.5 vs 92.9

N.S.

4.7 vs 3.6

N.S.

100 vs 100

N.A

100 vs 100

N.A

100 vs 100

N.A

South Korea

28 PUD; 37 NUD

83.3 vs 73.7

N.S.

16.7 vs 26.3

N.S.

100 vs 100

N.A

100 vs 100

N.A

100 vs 100

N.A

  1. Among the 415 isolates initially included, 43 (36 PUD strains and 7 NUD) harbored both homA and homB genes and were excluded from further analyses. These 49 isolates comprised all the 11 isolates from Burkina Faso.
  2. † p-value was determined by the Fisher's Exact Test.
  3. OR, odds ratio.
  4. N.S., not significant.
  5. N.A, not applicable.
  6. PUD, peptic ulcer disease
  7. NUD, non-ulcer dyspepsia