Table 1 Tested extraintestinal E. coli (ExPEC)-typical virulence associated genes (VAGs).
Gene(s) or operon | Description |
|---|---|
Adhesins | |
afa/draB | Afimbrial/Dr antigen-specific adhesin |
crl | Curli fiber gene |
fimC | Type 1 fimbriae (D-mannose specific adhesin) |
hra | Heat-resistant agglutinin |
iha | Iron-regulated-gene-homologue adhesin |
papC | Pilus associated with pyelonephritis |
sfa/focCD | S fimbriae (sialic acid-specific) and F1C fimbriae |
tsh 1 | Temperature sensitive hemagglutinin |
mat | Meningitis associated and temperature regulated fimbriae |
Iron acquisition | |
chuA | Heme receptor gene (E. coli haem utilization) |
fyuA | Ferric yersinia uptake (yersiniabactin receptor) |
ireA | Iron-responsive element (putative catecholate siderophore receptor) |
iroN 1 | Catecholate siderophore (salmochelin) receptor |
irp2 | Iron repressible protein (yersiniabactin synthesis) |
iucD 1 | Aerobactin synthesis |
sitD chr. | Salmonella iron transport system gene |
sitD ep.1 | Salmonella iron transport system gene |
Protectins/Serum resistance | |
cvi/cva 1 | Structural genes of colicin V operon (Microcin ColV) |
iss 1 | Increased serum survival |
neuC | K1 capsular polysaccharide |
kpsMT II | Group II capsule antigens |
ompA | Outer membrane protein |
traT 1 | Transfer Protein |
Toxins | Â |
astA | EAST1 (heat stable cytotoxin associated with enteroaggregative E. coli) |
sat | Secreted autotransporter toxin |
vat | Vacuolating autotransporter toxin |
hlyA | Haemolysin A |
Invasins | Â |
gimB | Genetic island associated with newborn meningitis |
ibeA | Invasion of brain endothelium |
tia | Toxigenic invasion locus in ETEC strains |
Miscellaneous | Â |
pic | Serin protease autotransporter |
malX | Pathogenicity-associated island marker CFT073 |