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Table 5 Serum immunoglobulin concentrations in probands with idiopathic parkinsonism and controls.

From: Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease

Serum concentration

Geometric mean (95% data interval)a

 
 

Probands

Controls

Covariatesb

 

n = 120

n = 205

 

IgM (g/l)

0.92 (0.30, 2.79)

0.90 (0.24, 3.35)

age, Helicobacter status*

IgG (g/l)

11.39 (6.11, 21.21)

11.92 (7.33, 19.39)

gender**

IgA (g/l)

2.95 (1.12, 7.79)

3.13 (1.15, 8.46)

age, gender***

IgA1 (mg/l)

1574 (538, 4606)

1652 (569, 4797)

 

IgA2 (mg/l)

406 (106, 1557)

388 (97, 1552)

 
  1. Demographic definition:- Mean age: 71 (sd 11.7, range 40-89) years in probands, 65.0 (15.9, 30-89) in controls. Percentage of males same (51%). Height not significantly different. Weight greater in controls (mean difference 4.00 (95% CI: 1.25, 6.75) kg). Affect score (20-point: median 5 (interquartile range 9, 3) in probands & 3 (5, 2) in controls) and cognitive function score (16-point: 14.5 (12.8, 15.5) & 15 (14.5, 16)) were consistent with exclusion of depression and clinical dementia. Median (interquartile) social status, by UK Registrar General's Social Classification, was the same in probands and controls. Severity of parkinsonism, by Hoehn and Yahr [40] Staging (I-V) of functional impairment: 31% of probands stage II, 38% stage III, 31% IV. Individual anti-parkinsonian drug categories used were levodopa/decarboxylase inhibitor combination (81.7% probands), dopamine agonist (20%), selegiline (55%) and antimuscarinics (17.5%), whilst 7.5% were untreated.
  2. a Values adjusted to age 60 years, and as if all subjects male.
  3. b Previously determined in controls [29]:-
  4. * IgM decreased overall by 1.04 (95% CI: 0.50, 1.58)% per year (p < 0.001). IgM was lower by 19.75 (3.80, 33.05)% (p = 0.02) in H. pylori ELISA-seropositive than in seronegative. Effect of seropositivity equivalent to 25 years of ageing, irrespective of current age.
  5. ** IgG higher in males (p = 0.002).
  6. *** IgA higher in males (p < 0.001), and increased with age (p = 0.007). Relationship of IgA1 to age was quadratic (p = 0.003, with respect to quadratic term), decreasing towards an estimated turning point of 57 years, then increasing. Relationship of IgA2 to age had quadratic trend (p = 0.1), in mirror image with similar turning point.
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Gut Pathogens

ISSN: 1757-4749