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Table 1 Differentially regulated MAP genes after D157070 treatment

From: A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis

   Fold Change   
Gene Name p-value Day 1 Day 3 Putative function MTB homologue
Upregulated
MAP0493c (acrR) 0.044 2.92 1.42 transcriptional regulator NS
MAP0494 0.011 3.37 1.66 hypothetical protein NS
MAP0495c 0.002 2.24 1.26 hypothetical protein Rv3572
MAP0496c 0.016 3.10 1.69 oxidoreductase Rv3571
MAP1369 (pks10) 0.044 2.43 1.77 polyketide synthase Rv1660
MAP1371 (pks8) 0.009 2.47 1.93 polyketide synthase Rv1662
MAP1724c (yceJ) 0.011 4.21 1.94 cytochrome like protein NS
MAP1725c (srpA) 0.021 5.02 2.81 catalase like protein NS
MAP2634c (smtA) 0.044 2.78 2.67 hypothetical protein Rv1147
MAP2635c (mmpl13) 0.002 3.73 1.93 mmpL protein Rv1146/5
MAP2642 0.001 9.00 3.59 naringenin-chalcone synthase Rv1660
MAP2643 0.001 7.93 3.20 methyltransferase Rv1139c
MAP2644 0.001 4.90 2.23 oxidoreductase Rv1138c
MAP2940c (dxr) 0.016 2.49 2.43 reductoisomerase Rv2870c
MAP2941c 0.009 6.75 3.78 cytochrome C biogenesis protein Rv2877c
MAP2942c (mpt53) 0.031 7.43 3.07 Mpt53 Rv2878c
MAP3545 0.016 2.45 1.73 oxidoreductase Rv3230c
MAP3546 (desA3_2) 0.016 3.02 1.90 DesA3_2 Rv3229c
MAP4201 (δL) 0.018 2.60 1.53 RNA polymerase sigma-L factor Rv0735
MAP4202 (rslA) 0.019 2.50 1.59 hypothetical protein Rv0736
MAP4203 0.007 3.34 2.19 oxidoreductase NS
MAP4204 0.012 2.74 2.01 hypothetical protein Rv1888c
MAP4205 (UbiE) 0.002 3.94 2.25 methyltransferase NS
MAP4206c (lolC) 0.017 4.06 3.36 efflux ABC transporter NS
MAP4207c (lolD) 0.003 5.91 2.77 ABC-type transporter NS
MAP4208 (ilvB) 0.002 6.93 3.40 acetolactate synthase Rv3740c
MAP4209 0.000 7.41 3.97 transcriptional regulator NS
MAP4210 (fabH) 0.005 7.04 4.24 3-oxoacyl-ACP synthase III Rv0533c
MAP4211 (pat) 0.003 6.19 4.82 histidinol-phosphate aminotransferase Rv3772
Downregulated
MAP1553c (fadE14) 0.009 2.27 1.88 putative acyl-CoA dehydrogenase Rv1346
MAP1554c (fadD33_2) 0.018 2.50 2.50 acyl-CoA synthase Rv1345
MAP1555c 0.017 2.50 1.45 acyl carrier protein Rv1344
MAP1668c (katG) 0.016 2.50 1.81 catalase/peroxidase Rv1908c
MAP1996 (fabD) 0.022 1.92 0.76 malonyl CoA-acyl carrier protein Rv2243
MAP2331c (acpS) 0.016 2.32 2.85 holo- [acyl-carrier-protein] synthase Rv2523c
MAP2332c (fas) 0.002 2.70 4.76 fatty acid synthase Rv2524c
MAP3177 0.018 2.70 2.22 hypothetical protein Rv3129
MAP3178c 0.016 3.12 1.12 hypothetical protein NS
MAP3179c 0.044 3.33 1.61 hypothetical protein Rv3134c
MAP3272 0.027 2.70 1.22 pyridoxamine 5'-phosphate oxidase Rv3129
MAP3273c 0.027 3.22 1.63 hypothetical protein Rv3131
MAP3600 0.032 1.85 2.04 hypothetical protein Rv0166
MAP3601 (fadD5) 0.006 2.43 4.00 acyl-CoA synthase Rv0166
MAP3602 0.047 2.00 2.04 hypothetical protein Rv0167
MAP3606 0.016 2.38 3.44 mce-family protein mce1c Rv0171
MAP3607 0.017 1.96 1.63 mce-family protein mce1d Rv0172
MAP3671 0.009 2.70 1.96 transcriptional regulator Rv0232
  1. Selected gene list with putative function predictions showing fold change of upregulated and downregulated operons (p < 0.05) of Day 1 D157070 treatment normalized to untreated control. Genes with homologues in MTB are indicated (NS = no significant homology).