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Table 1 Differentially regulated MAP genes after D157070 treatment

From: A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis

  

Fold Change

  

Gene Name

p-value

Day 1

Day 3

Putative function

MTB homologue

Upregulated

MAP0493c (acrR)

0.044

2.92

1.42

transcriptional regulator

NS

MAP0494

0.011

3.37

1.66

hypothetical protein

NS

MAP0495c

0.002

2.24

1.26

hypothetical protein

Rv3572

MAP0496c

0.016

3.10

1.69

oxidoreductase

Rv3571

MAP1369 (pks10)

0.044

2.43

1.77

polyketide synthase

Rv1660

MAP1371 (pks8)

0.009

2.47

1.93

polyketide synthase

Rv1662

MAP1724c (yceJ)

0.011

4.21

1.94

cytochrome like protein

NS

MAP1725c (srpA)

0.021

5.02

2.81

catalase like protein

NS

MAP2634c (smtA)

0.044

2.78

2.67

hypothetical protein

Rv1147

MAP2635c (mmpl13)

0.002

3.73

1.93

mmpL protein

Rv1146/5

MAP2642

0.001

9.00

3.59

naringenin-chalcone synthase

Rv1660

MAP2643

0.001

7.93

3.20

methyltransferase

Rv1139c

MAP2644

0.001

4.90

2.23

oxidoreductase

Rv1138c

MAP2940c (dxr)

0.016

2.49

2.43

reductoisomerase

Rv2870c

MAP2941c

0.009

6.75

3.78

cytochrome C biogenesis protein

Rv2877c

MAP2942c (mpt53)

0.031

7.43

3.07

Mpt53

Rv2878c

MAP3545

0.016

2.45

1.73

oxidoreductase

Rv3230c

MAP3546 (desA3_2)

0.016

3.02

1.90

DesA3_2

Rv3229c

MAP4201 (δL)

0.018

2.60

1.53

RNA polymerase sigma-L factor

Rv0735

MAP4202 (rslA)

0.019

2.50

1.59

hypothetical protein

Rv0736

MAP4203

0.007

3.34

2.19

oxidoreductase

NS

MAP4204

0.012

2.74

2.01

hypothetical protein

Rv1888c

MAP4205 (UbiE)

0.002

3.94

2.25

methyltransferase

NS

MAP4206c (lolC)

0.017

4.06

3.36

efflux ABC transporter

NS

MAP4207c (lolD)

0.003

5.91

2.77

ABC-type transporter

NS

MAP4208 (ilvB)

0.002

6.93

3.40

acetolactate synthase

Rv3740c

MAP4209

0.000

7.41

3.97

transcriptional regulator

NS

MAP4210 (fabH)

0.005

7.04

4.24

3-oxoacyl-ACP synthase III

Rv0533c

MAP4211 (pat)

0.003

6.19

4.82

histidinol-phosphate aminotransferase

Rv3772

Downregulated

MAP1553c (fadE14)

0.009

2.27

1.88

putative acyl-CoA dehydrogenase

Rv1346

MAP1554c (fadD33_2)

0.018

2.50

2.50

acyl-CoA synthase

Rv1345

MAP1555c

0.017

2.50

1.45

acyl carrier protein

Rv1344

MAP1668c (katG)

0.016

2.50

1.81

catalase/peroxidase

Rv1908c

MAP1996 (fabD)

0.022

1.92

0.76

malonyl CoA-acyl carrier protein

Rv2243

MAP2331c (acpS)

0.016

2.32

2.85

holo- [acyl-carrier-protein] synthase

Rv2523c

MAP2332c (fas)

0.002

2.70

4.76

fatty acid synthase

Rv2524c

MAP3177

0.018

2.70

2.22

hypothetical protein

Rv3129

MAP3178c

0.016

3.12

1.12

hypothetical protein

NS

MAP3179c

0.044

3.33

1.61

hypothetical protein

Rv3134c

MAP3272

0.027

2.70

1.22

pyridoxamine 5'-phosphate oxidase

Rv3129

MAP3273c

0.027

3.22

1.63

hypothetical protein

Rv3131

MAP3600

0.032

1.85

2.04

hypothetical protein

Rv0166

MAP3601 (fadD5)

0.006

2.43

4.00

acyl-CoA synthase

Rv0166

MAP3602

0.047

2.00

2.04

hypothetical protein

Rv0167

MAP3606

0.016

2.38

3.44

mce-family protein mce1c

Rv0171

MAP3607

0.017

1.96

1.63

mce-family protein mce1d

Rv0172

MAP3671

0.009

2.70

1.96

transcriptional regulator

Rv0232

  1. Selected gene list with putative function predictions showing fold change of upregulated and downregulated operons (p < 0.05) of Day 1 D157070 treatment normalized to untreated control. Genes with homologues in MTB are indicated (NS = no significant homology).
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Gut Pathogens

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