Antimicrobial resistance patterns and prevalence of class 1 and 2 integrons in Shigella flexneri and Shigella sonnei isolated in Uzbekistan

Table 1 Antimicrobial agent susceptibilities and MIC ranges of Shigella isolates from Uzbekistan

Antimicrobial agent*	S. flexneri(n = 31)				S. sonnei(n = 21)				Breakpoint values (μg/ml)^\|\|
	Resistant isolates	MIC^†(μg/ml)			Resistant isolates	MIC (μg/ml)
	No (%)	Range	MIC₅₀^‡	MIC₉₀^§	No (%)	Range	MIC₅₀	MIC₉₀	R	I	S
Am	28(90.4)	2-512	256	512	1(4.8)	4-512	4	8	≥32	16	≤8
Cl	28(90.4)	4-256	128	256	1(4.8)	2-256	8	8	≥32	16	≤8
Te	29(93.5)	1-256	128	128	7(66.7)	1-256	128	256	≥16	8	≤4
Sxt	10(32.3)	0.5-128	2/38	128/2432	6(62)	0.5-128	128/2432	128/2432	≥4/76	N/A	≤2/38
Km	2(6.5)	4-128	8	16	1(4.8)	4-64	8	8	≥64	32	≤16
Str	31(100)	64-256	256	256	21(100)	256	256	256	≥64	32	≤16
Gm	1(3.2)	2-32	4	4	2(9.5)	1-64	2	2	≥16	8	≤4
Czn	1(3.2)	0.5-32	2	4	0(0.0)	1-4	2	2	≥32	16	≤8
Cpr	1(3.2)	0.03-64	0.25	0.5	0(0.0)	0.12-0.5	0.12	0.25	≥64	32	≤16
Cur	1(3.2)	1-64	4	4	0(0.0)	1-4	4	4	≥32	16	≤8
Ctz	1(3.2)	0.06-64	0.12	0.25	0(0.0)	0.06-0.5	0.12	0.25	≥32	16	≤8
NA	0(0.0)	0.12-0.5	0.12	0.5	1(4.8)	0.12-32	0.12	0.25	≥32	N/A	≤16
Cip	0(0.0)	0.008-0.016	0.008	0.016	1(4.8)	0.004-4	0.008	0.016	≥4	2	≤1

* Am = ampicillin, Cl = chloramphenicol, Te = tetracycline, Sxt = co-trimoxazole (trimethoprim- sulfamethoxazole), Km = kanamycin, Str = streptomycin, Gm = gentamicin, Czn = cefazolin, Cpr = cefoperazone, Cur = cefuroxime, Ctz = ceftazidime, NA = nalidixic acid, Cip = ciprofloxacin
† MIC = Minimal inhibitory concentration; ‡ MIC₅₀ = MIC inhibiting 50% of isolates; § MIC₉₀ = MIC inhibiting 90% of isolates; || - intermediate resistant isolates were considered as resistant

ISSN: 1757-4749