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Table 1 Antimicrobial agent susceptibilities and MIC ranges of Shigella isolates from Uzbekistan

From: Antimicrobial resistance patterns and prevalence of class 1 and 2 integrons in Shigella flexneri and Shigella sonnei isolated in Uzbekistan

Antimicrobial agent* S. flexneri(n = 31) S. sonnei(n = 21) Breakpoint values (μg/ml)||
  Resistant isolates MIC(μg/ml) Resistant isolates MIC (μg/ml)    
  No (%) Range MIC50 MIC90§ No (%) Range MIC50 MIC90 R I S
Am 28(90.4) 2-512 256 512 1(4.8) 4-512 4 8 ≥32 16 ≤8
Cl 28(90.4) 4-256 128 256 1(4.8) 2-256 8 8 ≥32 16 ≤8
Te 29(93.5) 1-256 128 128 7(66.7) 1-256 128 256 ≥16 8 ≤4
Sxt 10(32.3) 0.5-128 2/38 128/2432 6(62) 0.5-128 128/2432 128/2432 ≥4/76 N/A ≤2/38
Km 2(6.5) 4-128 8 16 1(4.8) 4-64 8 8 ≥64 32 ≤16
Str 31(100) 64-256 256 256 21(100) 256 256 256 ≥64 32 ≤16
Gm 1(3.2) 2-32 4 4 2(9.5) 1-64 2 2 ≥16 8 ≤4
Czn 1(3.2) 0.5-32 2 4 0(0.0) 1-4 2 2 ≥32 16 ≤8
Cpr 1(3.2) 0.03-64 0.25 0.5 0(0.0) 0.12-0.5 0.12 0.25 ≥64 32 ≤16
Cur 1(3.2) 1-64 4 4 0(0.0) 1-4 4 4 ≥32 16 ≤8
Ctz 1(3.2) 0.06-64 0.12 0.25 0(0.0) 0.06-0.5 0.12 0.25 ≥32 16 ≤8
NA 0(0.0) 0.12-0.5 0.12 0.5 1(4.8) 0.12-32 0.12 0.25 ≥32 N/A ≤16
Cip 0(0.0) 0.008-0.016 0.008 0.016 1(4.8) 0.004-4 0.008 0.016 ≥4 2 ≤1
  1. * Am = ampicillin, Cl = chloramphenicol, Te = tetracycline, Sxt = co-trimoxazole (trimethoprim- sulfamethoxazole), Km = kanamycin, Str = streptomycin, Gm = gentamicin, Czn = cefazolin, Cpr = cefoperazone, Cur = cefuroxime, Ctz = ceftazidime, NA = nalidixic acid, Cip = ciprofloxacin
  2. † MIC = Minimal inhibitory concentration; ‡ MIC50 = MIC inhibiting 50% of isolates; § MIC90 = MIC inhibiting 90% of isolates; || - intermediate resistant isolates were considered as resistant