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Table 1 Properties of aac(6')-Ib-positive clinical isolates and transformant and transconjugant strains

From: Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy

Isolate ID

Bacterial species

qnr gene

aac(6') -Ib gene

MIC (mg/L)

GyrA

ParC

ESBLi phen

ESBL genotypic

ERIC

    

NA d

CPF e

OFX f

LVF g

MXF h

     

6

Escherichia coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

-

-

1

6Ta

E. coli TOP10

cr

-

0.008

0.008

0.016

0.004

0.006

-

-

nd

-

 

13

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

-

CTX-M-1

1

13Cb

J53AzKanNaR

cr

-

0.064

0.064

0.047

0.047

0.023

-

-

nd

CTX-M-1

 

13T

E. coli TOP10

cr

-

0.008

0.008

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

19

E. coli

non-cr

-

     

nd

nd

nd

nd

 

23

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1+TEM-1

2

23C

J53AzKanNaR

cr

-

0.047

0.047

0.047

0.047

0.032

-

-

nd

CTX-M-1+TEM-1

 

23T

E. coli TOP10

cr

-

0.004

0.004

0.016

0.004

0.006

-

-

nd

CTX-M-1+TEM-1

 

37

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

37T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1+TEM-1

 

39

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1

3

39T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

40

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

40T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1+TEM-1

 

44

E. coli

cr

-

0.047

0.047

0.032

0.047

0.023

-

-

X

CTX-M-1

3

44C

J53AzKanNaR

cr

-

0.047

0.047

0.047

0.047

0.023

-

-

nd

CTX-M-1

 

44T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

51

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1

1

51T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

52

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1

1

52T

E. coli TOP10

cr

-

0.004

0.004

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

53

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1

1

53T

E. coli TOP10

cr

-

0.004

0.004

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

111

Klebsiella pneumoniae

non-cr

qnrB19

1.5

1.5

4

2

nd

nd

nd

X

TEM-1+SHV-12

 

128

K. pneumoniae

non-cr

-

1.5

1.5

3

2

2

nd

nd

nd

nd

 

137

K. pneumoniae

non-cr

qnrB19

1

1

4

1.5

1.5

nd

nd

X

TEM-1

 

143

K. pneumoniae

non-cr

qnrB19

1.5

1.5

4

1.5

1.5

nd

nd

-

TEM-150+SHV-12

 

144

K. pneumoniae

non-cr

qnrB19

1.5

1.5

6

1.5

1.5

nd

nd

X

TEM-150

 

164

E. coli

cr

-

≥ 4

≥ 4

≥ 16

≥ 16

≥ 16

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

164T

E. coli TOP10

cr

-

0.004

0.004

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

175

E. coli

cr

-

≥ 4

≥ 4

nd

≥ 8

≥ 8

S83L, D87N

E84V

X

CTX-M-1

1

175T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

176

K. pneumoniae

non-cr

qnrB19

1

1

2

1.5

≥ 8

nd

nd

-

TEM-150

 

178

E. coli

cr

-

≥ 4

≥ 4

nd

≥ 8

≥ 8

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

178T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1+TEM-1

 

180

K. pneumoniae

non-cr

-

0.25

0.25

0.75

0.25

0.38

nd

nd

X

nd

 

182

E. coli

cr

-

≥ 4

≥ 4

≥ 8

≥ 8

≥ 8

S83L, D87N

E84V

X

CTX-M-1

1

182T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1

 

183

Enterobacter aerogenes

non-cr

-

0.75

0.75

2

1

0.75

nd

nd

nd

nd

 

184

E. coli

cr

-

≥ 4

≥ 4

nd

≥ 8

≥ 8

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

184T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

  

nd

CTX-M-1+TEM-1

 

185

E. coli

cr

-

≥ 4

≥ 4

nd

≥ 8

≥ 8

S83L, D87N

E84V

X

CTX-M-1+TEM-1

1

185T

E. coli TOP10

cr

-

0.006

0.006

0.016

0.004

0.006

-

-

nd

CTX-M-1+TEM-1

 
 

E. coli TOP10

-

-

0.016

0.016

0.047

0.047

0.023

-

-

nd

-

 
 

J53AzKanR

-

-

0.002

0.002

0.016

0.004

0.006

-

-

nd

-

 
  1. aT = tranformant strain; bC: transconjugant strain. dNA = nalidixic acid, eCPF = ciprofloxacin, fOFX = ofloxacin, gLVF = levofloxacin, hMXF = moxifloxacin. iESBL phen = ESBL phenotypic determination.
  2. nd = not determined
  3. - = negative
  4. Resistance ranges: nalidixic acid S ≤ 16 mg/L, R ≥ 32 mg/L; ciprofloxacin S ≤ 1 mg/L, I = 2 mg/L, R ≥ 4 mg/L; ofloxacin, levofloxacin, moxifloxacin S ≤ 2 mg/L, I = 4 mg/L, R ≥ 8 mg/L.
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Gut Pathogens

ISSN: 1757-4749