Figure 5

Representative colonic histology pictures (day 16). The pictures are from hematoxylin and eosin (H&E) stained colonic specimens, at a magnification of 200-fold. Panel A shows a normal histological appearance within the colon of a mouse that was not infected with C. difficile. Panel B is from the colon of a Vehicle/C. difficile treated mouse. There is evidence of crypt damage, submucosal edema and the influx of inflammatory cells in the lamina propria and sub-mucosa. Panel C is from the colon of a BC30/C. difficile treated animal. Although, colonic pathology is still present, it is less prominent than in panel B.