From: Treating critically ill patients with probiotics: Beneficial or dangerous?
Study | Study design | Number of patients | Probiotics/Synbiotics | Results |
---|---|---|---|---|
Alberda et al. [15] | double-blind, randomized, placebo-control. | 28 ICU patients: 14 verum vs 14 placebo. | 9 × 1011 L. casei, L. plantarum, Strept. salivarius, B. infantis L. acidophilus, B. longum, L. delbrueckii, B. breve. | increase in IgA + IgG in verum group. |
Spindler-Vessel et al. [16] | nonblinded, randomized, nonplacebo. | 113 ICU trauma pat.: 87 verum vs 26 placebo. | 1010 of P. pentosaceus, 1010 L. paracasei,1010 L. plantarum + 2,5 g ß-glucan, inulin, pectin, starch. | reduction in: pneumonias+ intestinal permeability + procalcitonin levels. |
Olah et al. [17] | double-blind, randomized, placebo-control. | 45 patients with acute pancreatitis: 23 vs 22 | 109 L plantarum 299 vs heat killed bacteria + 10 g oat fibre. | less septic complications in verum group. |
Forestier et al. [18] | double-blind, randomized, placebo-control. | 208 ICU patients: 104 verum vs104 placebo. | 109 Lact. rhamnosus, 109 Lact. casei. | P. aeruginosa colonization + infection is delayed in verum. |
Kotzampassi et al. [19] | double-blind, randomized, placebo-control. | 65 ICU trauma pat.:32 verum vs 33 placebo. | Synbiotic 2000 Forte. | reduced rate of infection, SIRS, severe sepsis + mortality in verum. |
Klarin et al. [20] | nonblinded, randomized, nonplacebo. | 44 ICU patients: 22 verum vs 22 | 109 Lact. plantarum 299v + oatmeal. | colonisation of C. difficile not detectable in verum group. |
Morrow et al. [21] | double-blind, randomized, placebo-control. | 146 ICU patients: 73 verum vs 73 placebo. | 1010 Lact. rhamnosus GG109 Lact. casei. | development of VAP less likely + less CDAD in verum group. |
Frohmader et al. [22] | double-blind, randomized, placebo control. | 45 ICU patients: 20 verum vs 25 placebo. | VSL#3. | effective in reducing frequency of liquid stool. |