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Table 2 The appearance of megasomes in H. pylori-infected primary human macrophages correlates with acquisition of EEA1 and Rab7 and the intracellular position of the bacteria.

From: Helicobacter pylori phagosome maturation in primary human macrophages

H. pylori strain Time after infection EEA1 colocalisation Rab7 colocalisation Intracellular position Megasomes
NL101 0 min + - CS/P -
  15 min + + Cy -
  30 min + + PN +
  2 hr + + PN +
  4 hr + + PN +
NL103 0 min + - CS/P -
  15 min + - CS/P -
  30 min + - Cy -
  2 hr + + PN +
  4 hr + + PN +
NL106 0 min + - CS/P -
  15 min + - CS/P -
  30 min + - Cy -
  2 hr + - PN +
  4 hr + + PN +
NL107 0 min - + CS/P -
  15 min + + PN +
  30 min + + PN +
  2 hr + + PN +
  4 hr + + PN +
SS1 0 min - - CS/P -
  15 min + + Cy -
  30 min + + PN +
  2 hr + + PN +
  4 hr + + PN +
  1. H. pylori clinical strains: NL101, NL103, NL106, NL107, SS1. Time after infection of primary human macrophages: 0 minutes, 15 minutes, 30 minutes, 2 hours and 4 hours. Intracellular position of H. pylori strains in infected primary human macrophages: CS/P; cell surface/periphery, Cy: cytoplasmic, PN: peri-nuclear. Association of EEA1/Rab7 with H. pylori phagosomes and appearance of megasomes is either present (+) or absent (-).