Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study

Table 1 Inclusion and exclusion criteria for surveillance

Inclusion
1.	Independently-living subjects with clinically-definite^a idiopathic parkinsonism
2.	Taking no or stable anti-parkinsonian medication
3.	Caucasian with English as first language and living in UK^b
Exclusion
1.	Secondary parkinsonism, ‘parkinsonism-plus’ syndromes and other wider clinical entities[70]
2.	Clinical depression[71], dementia[72] or other mental illness
3.	Other specific neurological condition
4.	Inflammatory bowel disease or history of major gastrointestinal surgery
5.	Other progressive or resolving disorders affecting physical ability or performance, or underlying incapacity sufficient to prevent assessments (e.g. use of walking aid)
6.	Cardiovascular/respiratory symptoms during normal activities
7.	UK MRC muscle strength score <4/5
8.	Arthropathy, mucsulo-skeletal disorder or overt abnormalities of, or history of orthopaedic surgery to, joints of spine or lower limbs
9.	Concurrent therapy with drugs which might be anti-dopaminergic or with hypnotics or sedatives
10.	Recent change in life situation (e.g. bereavement or change in marital status/domicile)

^aAny combination of three of the cardinal features: resting tremor, rigidity, bradykinesia or impairment of postural reflexes. Alternatively sufficient two of the four features, with one of first three asymmetrical[42]. Responsiveness to a dopaminergic drug challenge not a requirement.
^bTo constrain ethnic and/or geographical influences.

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