Figure 3
Stool consistency data. A) Mice were randomized on study day 6 to one of four treatment groups. All mice in the negative control group (n=6) that did not receive C. difficile (black symbols, lines) generally had normal stools throughout the study. Stool consistency scores were higher in the group of mice (blue symbols, bars) that were treated with Vehicle/C. difficile/No Vanco. In these animals, disease was prominently present on days 7 to 9. For the other two experimental groups, mice received Vehicle/C. difficile/Vanco and either Vehicle (red symbols, lines) to induce disease recurrence (study days 11 to 17), or BC30 at a dose of 2 x 109 CFU per day (green symbols, lines). * indicates p < 0.05 vs. BC30/C. difficile/Vanco treatment group on study days 13 through 17. B) The percentages of mice with normal stools in the Vehicle/C. difficile/Vanco (red symbols, lines) and BC30/C. difficile/Vanco (green symbols/lines) treatment groups is shown in this panel. Data are shown for study days 10 through 17. On days 14 through 17, significant differences (* p < 0.05) were found in the percentages of mice with normal stools in the Vehicle/BC30/Vanco group as compared to the Vehicle/C. difficile/Vanco group. On day 17, 88.9% of mice treated with BC30 had normal stools while this value was 0% with vehicle treatment.