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Figure 5 | Gut Pathogens

Figure 5

From: Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice

Figure 5

Colonic histology. Representative histology pictures from hematoxylin and eosin (H&E) stained colonic specimens are shown at a magnification of 200-fold. A) A relatively normal histological appearance is evident in the colon from a mouse not infected with C. difficile. B) Evidence of crypt damage, submucosal edema and the influx of inflammatory cells in the lamina propria and sub-mucosa is present in the colon of an animal infected with C. difficile but not treated with Vanco. C) In the colon of a mouse given C. difficile plus Vanco, there is evidence of crypt disruption, leukocyte influx and prominent sub-mucosal edema. D) Mild pathology is observed in the colon of a BC30 treated mouse that was also given C. difficile plus Vanco. Modest leukocyte influx is present in the lamina propria, as well as limited sub-mucosal edema, when compared to the vehicle control (compare panels C and D). E) This panel shows a summary of the colonic histology score data. * p < 0.05 vs. Vehicle/C. difficile/Vanco treatment group (compare red and green bars in the graph).

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