Table 1 Levels of proinflammatory cytokines, TNF-α, IL-1 and IL-2, in intranasally infected mice with C. jejuni (mean ± SD)
Organ | Group | Day 1 | Day 3 | Day 5 | Day 10 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | ||
Spleen | Test | 1042 (±32) * | 270 (±59) | 153 (±39)* | 478 (±340) | 861 (±387)* | 181 (±16) | 114 (±16) | 1094 (±208) * | 70 (±39) | 138 (±26) | 852 (±183) | 78 (±19) |
Control | 245 (±31) | 814 (±262) | 87 (±27) | 1045 (±57) | 319 (±89) | 105 (±51) | 218 (±65) | 717 (±62) | 170 (±92) | 182 (±16) | 1186 (±381) | 55 (±13) | |
Large intestine | Test | 110 (±59)* | 111 (±12) | 471 (±655) | 20 (±5) | 147 (±127) | 1634 (±918) | 13 (±3) | 161 (±40)* | 5752 (±1251)* | 6 (±7) | 101 (±35) | ND |
Control | 13 (±6) | 141 (±10) | 5416 (±1057) | 109 (±61) | 144 (±59) | 1707 (±739) | 15 (±11) | 62 (±47) | 2216 (±705) | 16 (±1) | 159 (±44) | ND | |
Liver | Test | 186 (±17) | 50 (±21) | 256 (±129) | 4581 (±4244) | 133 (±33)* | 1209 (±745)* | 3860 (±1000) | 118 (±34) | 389 (±69) | ND | 126 (±7) | 64 (±22) |
Control | 4567 (±1992) | 73 (±25) | 718 (±297) | 4425 (±992) | 79 (±26) | 458 (±116) | 4183 (±273) | 142 (±72) | 366 (±102) | ND | 148 (±31) | 55 (±8) | |
Small intestine | Test | 7 (±6) | 12 (±9) | 2483 (±286) | 11 (±2) | 6 (±0) | 2063 (±428)* | 6 (±2) | 12 (±2) | 5427 (±756) | 13 (±3) | 4 (±1) | 3640 (±1737) |
Control | 16 (±13) | 142 (±37) | 7352 (±1909) | 11 (±2) | 11 (±6) | 830 (±335) | 11 (±1) | 112 (±25) | 5012 (±828) | 10 (±5) | 2 (±1) | 6603 (±379) | |
Serum | Test | 101 (±9)* | 55 (±13)* | 8 (±0) | 28 (±39) | 27 (±2) | 8 (±0) | 76 (±54) | 23 (±4)* | 8 (±0) | 45 (±39) | 23 (±1) | 8 (±0) |
Control | 29 (±14) | 8 (±9) | 8 (±0) | 100 (±5) | 16 (±11) | 8 (±0) | 43 (±36) | 3 (±0) | 8 (±0) | 85 (±14) | 28 (±3) | 8 (±0) | |