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Table 3 Summary of observed cytokine profiles and bacterial dissemination in intranasally infected mice with C. jejuni

From: Induction of cytokines in different organs after intranasal inoculation of Campylobacter jejuni in mice

Organ

Observation

Day 1

Day 3

Day 5

Day 10

Spleen

Proinflammatory cytokine

TNF-α, IL-2

IL-1

IL-1

-

Anti-inflammatory cytokine

IL-10

-

-

-

C. jejuni isolated

Yes

No

No

ND

Large intestine

Proinflammatory cytokine

TNF-α

-

IL-1, IL-2

-

Anti-inflammatory cytokine

-

-

IL-4, IL-10

-

C. jejuni isolated

Yes

Yes

Yes

ND

Liver

Proinflammatory cytokine

-

IL-1, IL-2

-

-

Anti-inflammatory cytokine

-

-

IL-4, IL-10

-

C. jejuni isolated

Yes

No

No

ND

Small intestine

Proinflammatory cytokine

-

IL-2

-

-

Anti-inflammatory cytokine

-

IL-4

IL-10

-

C. jejuni isolated

Yes

Yes

Yes

ND

Serum

Proinflammatory cytokine

TNF-α, IL-1

-

IL-1

-

Anti-inflammatory cytokine

IL-4

-

IL-4

-

C. jejuni isolated

Yes

No

No

ND

  1. Mention of cytokine indicates that cytokine level in test mice was significantly increased compared to in control mice; ND, culture not done;-, no difference between test mice and control mice.