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Table 3 Summary of observed cytokine profiles and bacterial dissemination in intranasally infected mice with C. jejuni

From: Induction of cytokines in different organs after intranasal inoculation of Campylobacter jejuni in mice

Organ Observation Day 1 Day 3 Day 5 Day 10
Spleen Proinflammatory cytokine TNF-α, IL-2 IL-1 IL-1 -
Anti-inflammatory cytokine IL-10 - - -
C. jejuni isolated Yes No No ND
Large intestine Proinflammatory cytokine TNF-α - IL-1, IL-2 -
Anti-inflammatory cytokine - - IL-4, IL-10 -
C. jejuni isolated Yes Yes Yes ND
Liver Proinflammatory cytokine - IL-1, IL-2 - -
Anti-inflammatory cytokine - - IL-4, IL-10 -
C. jejuni isolated Yes No No ND
Small intestine Proinflammatory cytokine - IL-2 - -
Anti-inflammatory cytokine - IL-4 IL-10 -
C. jejuni isolated Yes Yes Yes ND
Serum Proinflammatory cytokine TNF-α, IL-1 - IL-1 -
Anti-inflammatory cytokine IL-4 - IL-4 -
C. jejuni isolated Yes No No ND
  1. Mention of cytokine indicates that cytokine level in test mice was significantly increased compared to in control mice; ND, culture not done;-, no difference between test mice and control mice.