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Table 2 The distribution of LP/LNP genotypes and allele frequencies in patients with inflammatory bowel disease (IBD), Crohn’s disease (CD) ulcerative colitis (UC) and in controls (HC) [ n (%)]

From: Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease

  Allele
  Genotype Frequency %
Group CC-13910 1* CT-13910 2 TT-131910 2 C T
IBD ( n= 278) 64 (23.0) 138 (49.6) 76 (24.4)a 47.8 52.2
CD ( n= 173) 37 (21.4) 84 (48.6) 52 (30) 45.5 54.5
UC ( n= 105) 27 (25.7) 54 (51.4) 24 (22.9) b 51.4 48.6
HC ( n= 188) 35 (18.6) 81 (43.1) 72 (38.3) 40.2 59.8
  1. 1Lactase non-persistent genotype (LNP); 2Lactase persistent genotype (LP) *No significant differences were detected comparing LNP and LP genotypes between UC patients and CD patients (P = 0.409), CD patients and controls (P = 0.506) or IBD with controls (P = 0.255). Nearly significant differences comparing UC patients and controls (P = 0.154). Significant differences were detected when comparing TT genotype, aIBD and controls (P = 0.013) and bUC patients compared to controls (P = 0.0075). Nearly significant difference when comparing CD patients and controls (P = 0.1005).