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Table 2 The distribution of LP/LNP genotypes and allele frequencies in patients with inflammatory bowel disease (IBD), Crohn’s disease (CD) ulcerative colitis (UC) and in controls (HC) [ n (%)]

From: Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease

 

Allele

 

Genotype

Frequency %

Group

CC-13910 1*

CT-13910 2

TT-131910 2

C

T

IBD ( n= 278)

64 (23.0)

138 (49.6)

76 (24.4)a

47.8

52.2

CD ( n= 173)

37 (21.4)

84 (48.6)

52 (30)

45.5

54.5

UC ( n= 105)

27 (25.7)

54 (51.4)

24 (22.9) b

51.4

48.6

HC ( n= 188)

35 (18.6)

81 (43.1)

72 (38.3)

40.2

59.8

  1. 1Lactase non-persistent genotype (LNP); 2Lactase persistent genotype (LP) *No significant differences were detected comparing LNP and LP genotypes between UC patients and CD patients (P = 0.409), CD patients and controls (P = 0.506) or IBD with controls (P = 0.255). Nearly significant differences comparing UC patients and controls (P = 0.154). Significant differences were detected when comparing TT genotype, aIBD and controls (P = 0.013) and bUC patients compared to controls (P = 0.0075). Nearly significant difference when comparing CD patients and controls (P = 0.1005).