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Figure 1 | Gut Pathogens

Figure 1

From: The bioluminescent Listeria monocytogenes strain Xen32 is defective in flagella expression and highly attenuated in orally infected BALB/cJ mice

Figure 1

Listeria monocytogenes Xen32 strains show attenuated virulence in vivo. BALB/cJ mice (n = 10) were intragastrically inoculated with 1 × 1010 CFU Lmo-Xen32, Lmo-Xen32-mur, Lmo-EGDe-lux or Lmo-EGDe-mur-lux. (A) Serial BLI of 1 representative mouse from one hour until 7 days post infection as described in Methods (see also Additional file1: Figure S1 for reference). Colour bar indicates emitted light with 3 or 4 min integration time in photons/s/cm2/sr. un = uninfected control. (B) Survival rates of BALB/cJ mice (n = 10) after infection with 1 × 1010 CFU Lmo-Xen32, Lmo-Xen32-mur, Lmo-EGDe-lux or Lmo-EGDe-mur-lux. (C) Body weight loss of BALB/cJ mice infected with the same listerial strains and dosage as shown in (A) and (B). Graphs demonstrated mean in percent (n = 10) with standard error. Statistical significance between murinised (green stars) and non-murinised (yellow stars) Listeria strains are indicated (*p < 0.05, **p < 0.01, non-parametric Mann–Whitney-U-test).

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Gut Pathogens

ISSN: 1757-4749