LGG treatment protects intestine physiology after virus infection. (A) H&E staining of the pig ileum. Infiltration of immune cells (yellow arrow) and discontinued muscularis mucosae (green arrow) were present in pig ilea infected with HRV (10× magnification, scale bar 200 μm). (B) HRV increases claudin-2 protein in pig ileum. (C) Diagram showing the potential roles of LGG in HRV-infected pig ileum. While HRV increases autophagy to establish infection in epithelial cells, LGG inhibits autophagy and increases apoptosis to clear HRV-infected cells.