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Table 1 Case reports of Blastocystis infection

From: Update on the pathogenic potential and treatment options for Blastocystis sp

Patient Clinical history Diagnosis Treatment Outcome Study
One 11 y.o male and one 12 y.o male Both presented with right lower quadrant tenderness, anorexia, abdominal pain, nausea, vomiting Initially diagnosed with appendicitis. Stool examination showed Blastocystis and patients were then diagnosed with Blastocystis infection Metronidazole and co-trimoxazole Complete recovery [15]
24 y.o female Nine week history of urticaria, hives, chronic diarrhoea, IBS Initially diagnosed with cellulitis. Treated with non-steroidal cream with no recovery of symptoms. Presented with hives and diagnosed as urticaria. Extensive investigation showed 4 + Blastocystis in her stool. Metronidazole All urticarial and IBS symptoms cleared [24]
45 y.o female Four month history of erythematous and pruriginous lesions on trunk and limbs, mild gastoenteric complaints Diagnosed with urticaria. Extensive investigation showed the stool postive for Blastoycstis. Paromomycin and metronidazole All urticarial and gastrointestinal symproms cleared [25]
32 y.o female Four year history of allegic rhinitis and chronic urticaria, swelling in pressure sites Diagnosed with delayed pressure urticaria. Treated with systemic corticosteroids with only partial clearance of symptoms. Stool examination positive for Blastocystis Metronidazole All urticarial symptoms cleared [26]
60 y.o female Four year history of anaphylactoid reactions, severe asthma and generalised urticaria Diagnosed with chronic urticaria. Extensive investigation identified Blastocystis in the stool Paromomycin All urticaria symptoms cleared [27]
74 y.o male Diarrhoea, abdominal pain, nausea, fatigue and fever Hospitalised. Stool were positive for Blastocystis Metronidazole Clearence of symptoms after 10days [18]
29 y.o female Six month history of morning stiffness, pain and swelling of joints, elbows, ankles, knees, diarrhoea, abdominal pain and vomiting Treated for presumed infectious arthritis of the knee. No improvement. Microscopy of the synovial fluid and stools both showed the presence of Blastocystis. Metronidazole After two weeks knee inflammation subsided and all abdominal pain and diarrhoea were cleared [28]
24 y.o male Six week history of diffuse abdominal pain and diarrhoea Stool examination was positive for Blastocystis and Endolimax nana. Metronidazole Complete resolution of symptoms 10days later [29]
19 y.o male Three week history of hives, abdominal pain for 2.5months Diagnosed with acute urticaria. Routine testing showed the presence of Blastocystis in the stool ST3 Metronidazole 10days after treatment both urticaria and abdominal discomfort were cleared [21]
20 y.o male Urticaria and flatulence Treated with antihistamines with no success. Further investigation showed Blastocystis ST2 in the stool. Initially treated with metronidazole but treatment failure appears to have occured. Then treated with co-trimoxazole with no success and finally treated with combination metronidazole and paramomycin Metronidazole then co-trimoxazole followed by paromomycin All symptoms cleared 10 days later [22]
40 y.o female Hospitalised due to severe diarrhoea and fever Blastocystis ST8 infection diagnosed from stool cultures. Treated with metronidazole. Symptoms persisted and the patient also noted bloating, flatulence and abdominal pain. Further treated with co-trimoxazole Metronidazole then co-trimoxazole All symptoms cleared [30]