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Table 4 Differentially transcribed host genes up or down-regulated by >3-fold at 24 h after C. trachomatis persistent infection of LCC-18 cells compared to non-infected

From: Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study

Affymetrix ID

Gene name

Gene symbol

Log2 fold change

Absolute fold change

8027002

Growth differentiation factor 15

GDF15

3,32

10,01

7958262

t-complex 11 (mouse)-like 2

TCP11L2

2,96

7,79

7954090

Epithelial membrane protein 1

EMP1

2,59

6,03

8158671

Argininosuccinate synthetase 1

ASS1

2,10

4,29

8152703

F-box protein 32

FBXO32

2,09

4,25

7982868

ChaC, cation transport regulator homolog 1 (E. coli)

CHAC1

2,09

4,25

8048319

Villin 1

VIL1

-2,04

4,10

8066431

Adenosine deaminase

ADA

-2,00

3,99

8008885

microRNA 21

MIR21

1,99

3,96

8034122

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

SPC24

-1,96

3,89

8119898

Vascular endothelial growth factor A

VEGFA

1,91

3,77

8117429

Histone cluster 1, H2bi

HIST1H2BI

-1,88

3,69

7919591

Family with sequence similarity 72, member D /// family with sequence similarity 72,

FAM72D / FAM72A / FAM72B / FAM72C

-1,84

3,60

8122724

UL16 binding protein 1

ULBP1

1,81

3,49

8007071

Cell division cycle 6 homolog (S. cerevisiae)

CDC6

-1,80

3,49

8113073

Arrestin domain containing 3

ARRDC3

1,79

3,45

8068684

Family with sequence similarity 3, member B

FAM3B

-1,76

3,40

7989146

Meiosis-specific nuclear structural 1

MNS1

-1,70

3,24

8109712

Hyaluronan-mediated motility receptor (RHAMM)

HMMR

-1,68

3,20

8113278

Lix1 homolog (chicken)

LIX1

-1,66

3,15

7953943

GABA(A) receptor-associated protein like 1

GABARAPL1

1,65

3,15

8071212

CDC45 cell division cycle 45-like (S. cerevisiae)

CDC45L

-1,65

3,14

8009243

Chromosome 17 open reading frame 60

C17orf60

1,65

3,13

8062064

Myosin, heavy chain 7B, cardiac muscle, beta

MYH7B

-1,64

3,11

8021470

Phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1

1,62

3,08

8095744

Amphiregulin

AREG

1,62

3,08

7989647

KIAA0101 /// casein kinase 1, gamma 1

KIAA0101 /// CSNK1G1

-1,61

3,06

7914878

Arsenic transactivated protein 1

LOC100289612

-1,61

3,05

8165663

Glycerol-3-phosphate acyltransferase, mitochondrial

GPAM

-1,60

3,04

8077731

Fanconi anemia, complementation group D2

FANCD2

-1,59

3,03

8151871

Cyclin E2

CCNE2

-1,59

3,03

8157524

Toll-like receptor 4

TLR4

1,59

3,03

8104234

Thyroid hormone receptor interactor 13

TRIP13

-1,59

3,01

  1. Gene clustering based on Gene Ontology identified ten clusters: cell cycle, cell surface, regulation of apoptosis, organelle lumen, cytoskeleton, immune response, regulation of phosphorylation, cytokine activity, intrinsic to membrane and ion binding.