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Table 5 Differentially transcribed genes coding for solute carrier families (SLC), up or down-regulated at 24 h after C. trachomatis persistent infection of CNDT-2 and LCC-18 cells compared to non-infected

From: Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study

Affymetrix ID

Gene name

Gene symbol

Log2 fold change

Absolute fold change

Log2 fold change

Absolute fold change

LCC-18

LCC-18

CNDT-2

CNDT-2

PI v NI

PI v NI

PI v NI

PI v NI

   

Microarray/ qPCR

Microrray/qPCR

Microarray/qPCR

Microarray/qPCR

8042310

Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

SLC1A4

NC

NC

1,37

2,58

0,94

1,9

1,12

2,2

8068361

Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3

SLC5A3

1,2

2,3

NC

NC

1,28

2,4

0,18

1,1

8003298

Solute carrier family 7 (cationic amino acid transporter, y + system), member 5

SLC7A5

NC

NC

1,26

2,4

-0,6

1,4

0,48

1,4

8102800

Solute carrier family 7, (cationic amino acid transporter, y + system) member 11

SLC7A11

0,84

1,8

3,76

13,6

1,63

3,1

1.55

2,9

8017843

Solute carrier family 16, member 6 (monocarboxylic acid transporter 7

SLC16A6

1,26

2,4

0,88

1,8

0,68

1,6

1,67

3,2

8010673

Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

SLC25A10

-0,79

1,7

-1,07

2,1

-0,11

1,1

-1,49

2,5

8012450

Solute carrier family 25, member 35

SLC25A35

-0,96

2

-0,43

1,4

-0,49

1,4

-0,79

1,7

8162586

Solute carrier family 35,member D2 UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

SLC35D2

0,96

2

0,57

1,5

0,74

1,7

0,8

1,7

7962559

Solute carrier family 38, member 4, Na(+)-coupled neutral amino acid transporter

SLC38A4

1,48

2,8

-1,1

2,2

0,92

1,9

-0,56

1,4

7965964

Solute carrier family 41, member 2, plasma-membrane magnesium transporter

SLC41A2

0,4

1,3

1,18

2,3

   

0,45

1,4

1,62

3,1

  1. A fold change > 2 was observed in at least one comparison. Microarray results and validation of candidate genes using qPCR.
  2. PI = persistent infection, NI = non-infected cells. Log2 fold change “-“ = down- regulated,“+” = up-regulated. NC = no change.