Identification of potential driver and passenger bacteria associated with CRC and their co-occurrences. Unclassified taxa were represented by star. *FDR-corrected P < 0.05. (A) Potential driver bacteria whose relative abundances in adenoma tissues were significantly higher than in normal and tumor tissues; (B) Potential anti-inflammatory passenger bacteria whose relative abundances in adenoma tissues were significantly lower than in normal and tumor tissues; (C) Potential pro-inflammatory passenger bacteria whose relative abundances in normal tissues were significantly lower than in tumor or/and adenoma tissues; (D) Correlation relationships among three types of CRC bacteria as described (A)-(C). Each co-occurring pair has an absolute Spearman rank correlation above 0.50 with an FDR-corrected significance level under 0.05. Node labels are corresponding to bacterial taxa. Edges are colored by positive or negative correlations. Driver bacterial cluster was colored by green, anti-inflammatory passenger bacterial cluster by blue and pro-inflammatory passenger bacterial cluster by yellow.