Table 1 Antibiotic resistance genes detected in Clostridium sp. BL8 genome
Gene | Antibiotic class | Resistance tested against |
|---|---|---|
Aminoglycoside 6-adenylyltransferase | Aminoglycosides | Streptomycin, Amikacin |
GCN5-related N-acetyltransferase | Aminoglycosides | Gentamicin, Kanamycin |
Response regulator for bacitracin transporter BceR | Cyclic peptides | Colistin |
bacitracin ABC transporter, ATP-binding protein | Cyclic peptides | Colistin |
Metal-dependent beta-lactamase PhnP | Beta lactams | Penicillin-G |
Beta-lactamase (EC 3.5.2.6) | Beta lactams | Ampicillin |
Ribosome protection-type tetracycline resistance proteins | Tetracyclines | Tetracycline |
Tetracycline efflux pump TetA | Tetracyclines | Tetracycline |
Chloramphenicol acetyltransferase | Amphenicols | Chloramphenicol |
Zwittermicin A resistance protein ZmaR | Aminopolyol | NT |
Vancomycin B-type resistance protein VanW | Glycopeptides | Vancomycin |
Quinolone resistance protein | Quinolones | NT |
Macrolide-efflux protein | Macrolides | NT |
Erythromycin esterase | Macrolides | NT |
Erythromycin esterase type II | Macrolides | NT |
Dihydrofolate reductase | Sulfonamides | Cotrimoxazole |