Figure 2
From: Phase-variable restriction/modification systems are required for Helicobacter pylori colonization
Model for the function of phase variation in HP1471. Expression of the target recognition domain TRD1 in OND79 leads to specific methylation of DNA sequence recognized by TRD1 (WT), indicated in red. In OND79 HP1471::ON the homopolymeric repeat (G13) is removed allowing expression of TRD1 and TRD2 resulting in specific methylation at DNA sequence recognized by TRD1/TRD2 (ON), indicated in red and blue. In OND79 ?HP1471 neither TRD1 nor TRD2 are expressed leading to absence of methylation due to the non-functional methyltransferase (DEL).