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Table 4 Virulence-associated genes with significant association to o454-nlpD patterns

From: Correlation between the genomic o454-nlpD region polymorphisms, virulence gene equipment and phylogenetic group of extraintestinal Escherichia coli (ExPEC) enables pathotyping irrespective of host, disease and source of isolation

VAG

P-value

Association with pattern

Type of association

focG

1.18e-15

III

+

papAH

8.50e-25

III

+

papEF

3.83e-11

III

+

papG II/III

3.32e-20

III

+

sfa/foc

1.23e-33

III

+

sfaS

6.01e-15

III

+

fyuA

7.10e-25

III

+

ireA

1.99e-08

III

+

iroN

3.62e-40

III

+

irp2

7.14e-42

III

+

sitD chromosomal

6.87e-80

III

+

colV

0.000

III

+

iss

0.001

III

+

neuC

1.96e-28

III

+

cnf

1.30e-17

III

+

vat

2.41e-76

III

+

hlyA

1.39e-20

III

+

ibeA

3.96e-22

III

+

gimB

1.12e-35

III

+

malX

2.03e-94

III

+

pks

3.53e-49

III

+

puvA

6.94e-05

III

+

ea/I

1.59e-67

III

+

fimC

4.52e-06

III

-

mat

0.047

III

-

astA

0.002

III

-

hrA

3.39e-05

I, III

+

papC

2.31e-19

I, III

+

chuA

6.42e-78

I, III

+

kpsMTII

9.17e-42

I, III

+

ompT

0.001

III, IV

+

traT

0.034

III, IV

+

sat

0.007

I, III

+

hlyF

0.001

III, IV

+

tia

4.84e-05

I, III

+

pic

3.95e-14

III, IV

+

csgA

6.44e-85

I, III

-

iha

7.91e-05

II, III

-

  1. P-values obtained with Fisher’ exact test and type of association with Cohen-Friendly association plot. No significant association was observed for genes afa/draBC (p?=?0.463), bmaE (p?=?0.085), gafD (p?=?0.257), tsh (p?=?0.386), iucD (p?=?0.565), iutA (p?=?0.506), sitDepisomal (p?=?0.89), and ompA (p?=?0.354).