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Table 3 Association between H. pylori genotypes and chronic inflammation, neutrophil activity and peptic ulcer disease

From: Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East

H. pylorigenotypea(n)

Chronic inflammationb

Neutrophil activityb

Peptic Ulcer Disease

None-Mild

Moderate-Marked

OR (95% CI)c

p-value

None-Mild

Moderate-Marked

OR (95% CI)c

p-value

Absent

Present

OR (95% CI)c

p-value

(n 22)

(n 77)

(n 60)

(n 39)

(n 29)

(n 70)

n (%)

n (%)

  

n (%)

n (%)

  

n (%)

n (%)

  

cagA

            
 

Positive (52)

8 (15.4)

44 (84.6)

2.4 (0.9-6.7)

0.074

29 (55.8)

23 (44.2)

1.5 (0.6-3.4)

0.325

8 (15.4)

44 (84.6)

4.8 (1.8-12.5)

0.002*

 

Negative (47)

14 (29.8)

33 (70.2)

Reference

 

31 (66.0)

16 (34.0)

Reference

 

21 (44.7)

26 (55.3)

Reference

 

vacA-s1

            
 

Positive (44)

5 (11.4)

39 (88.6)

3.9 (1.2-12.0)

0.017*

22 (50.0)

22 (50.0)

2.2 (0.9-5.2)

0.057

8 (18.2)

36 (81.8)

2.8 (1.1-7.4)

0.031*

 

Negative (55)

17 (30.9)

38 (69.1)

Reference

 

38 (69.1)

17 (30.9)

Reference

 

21 (38.2)

34 (61.8)

Reference

 

vacA-s2

            
 

Positive (39)

13 (33.3)

26 (66.7)

0.3 (0.1-0.8)

0.025*

29 (74.4)

10 (25.6)

0.3 (0.1-0.8)

0.027*

17 (43.6)

22 (56.4)

0.3 (0.1-0.7)

0.011*

 

Negative (60)

9 (15.0)

51 (85.0)

Reference

 

31 (51.7)

29 (48.3)

Reference

 

12 (20.0)

48 (80.0)

Reference

 

vacA-s1?+?S2

            
 

Positive (10)

3 (30.0)

7 (70.0)

0.5 (0.1-2.2)

0.445

8 (80.0)

2 (20.0)

0.3 (0.0-1.7)

0.191

2 (20.0)

8 (80.0)

1.8 (0.3-9.1)

0.478

 

Negative (89)

19 (21.3)

70 (78.7)

Reference

 

52 (58.4)

37 (41.6)

Reference

 

27 (30.3)

62 (69.7)

Reference

 

cagA?+?vacA-s1

            
 

Positive (31)

2 (6.5)

29 (93.5)

6.7 (1.4-31.4)

0.016*

18 (58.1)

13 (41.9)

0.9 (0.9-1.0)

0.737

3 (9.7)

28 (90.3)

6.3 (1.6-23.4)

0.006*

 

Negative (68)

20 (20.9)

48 (70.6)

Reference

 

42 (61.8)

26 (38.2)

Reference

 

26 (38.2)

42 (61.8)

Reference

 

cagA?+?vacA-s2

            
 

Positive (8)

3 (37.5)

5 (62.5)

0.4 (0.1-2.2)

0.337

5 (62.5)

3 (37.5)

0.9 (0.2-4.3)

0.959

2 (25.0)

6 (75.0)

1.2 (0.2-6.5)

0.810

 

Negative (91)

19 (20.9)

72 (79.1)

Reference

 

55 (60.4)

36 (39.6)

Reference

 

27 (29.7)

64 (70.3)

Reference

 

cagA?+?vacA-s1?+?s2

            
 

Positive (7)

2 (28.6)

5 (71.4)

0.9 (0.9-1.0)

0.255

5 (71.4)

2 (39.4)

0.5 (0.1-3.2)

0.537

1 (14.3)

6 (85.7)

2.7 (0.3-24.5)

0.359

 

Negative (92)

20 (21.7)

72 (78.3)

Reference

 

55 (59.8)

37 (40.2)

Reference

 

28 (30.4)

64 (69.6)

Reference

 
  1. aAll patients were positive for either cagA, vacA or both.
  2. bAccording to the Updated Sydney system [40].
  3. cAge and gender adjusted odds ratio.
  4. *Statistically significant.