H. pylorigenotypea(n) | Chronic inflammationb | Neutrophil activityb | Peptic Ulcer Disease | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
None-Mild | Moderate-Marked | OR (95% CI)c | p-value | None-Mild | Moderate-Marked | OR (95% CI)c | p-value | Absent | Present | OR (95% CI)c | p-value | ||
(n 22) | (n 77) | (n 60) | (n 39) | (n 29) | (n 70) | ||||||||
n (%) | n (%) | Â | Â | n (%) | n (%) | Â | Â | n (%) | n (%) | Â | Â | ||
cagA | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (52) | 8 (15.4) | 44 (84.6) | 2.4 (0.9-6.7) | 0.074 | 29 (55.8) | 23 (44.2) | 1.5 (0.6-3.4) | 0.325 | 8 (15.4) | 44 (84.6) | 4.8 (1.8-12.5) | 0.002* |
 | Negative (47) | 14 (29.8) | 33 (70.2) | Reference |  | 31 (66.0) | 16 (34.0) | Reference |  | 21 (44.7) | 26 (55.3) | Reference |  |
vacA-s1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (44) | 5 (11.4) | 39 (88.6) | 3.9 (1.2-12.0) | 0.017* | 22 (50.0) | 22 (50.0) | 2.2 (0.9-5.2) | 0.057 | 8 (18.2) | 36 (81.8) | 2.8 (1.1-7.4) | 0.031* |
 | Negative (55) | 17 (30.9) | 38 (69.1) | Reference |  | 38 (69.1) | 17 (30.9) | Reference |  | 21 (38.2) | 34 (61.8) | Reference |  |
vacA-s2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (39) | 13 (33.3) | 26 (66.7) | 0.3 (0.1-0.8) | 0.025* | 29 (74.4) | 10 (25.6) | 0.3 (0.1-0.8) | 0.027* | 17 (43.6) | 22 (56.4) | 0.3 (0.1-0.7) | 0.011* |
 | Negative (60) | 9 (15.0) | 51 (85.0) | Reference |  | 31 (51.7) | 29 (48.3) | Reference |  | 12 (20.0) | 48 (80.0) | Reference |  |
vacA-s1?+?S2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (10) | 3 (30.0) | 7 (70.0) | 0.5 (0.1-2.2) | 0.445 | 8 (80.0) | 2 (20.0) | 0.3 (0.0-1.7) | 0.191 | 2 (20.0) | 8 (80.0) | 1.8 (0.3-9.1) | 0.478 |
 | Negative (89) | 19 (21.3) | 70 (78.7) | Reference |  | 52 (58.4) | 37 (41.6) | Reference |  | 27 (30.3) | 62 (69.7) | Reference |  |
cagA?+?vacA-s1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (31) | 2 (6.5) | 29 (93.5) | 6.7 (1.4-31.4) | 0.016* | 18 (58.1) | 13 (41.9) | 0.9 (0.9-1.0) | 0.737 | 3 (9.7) | 28 (90.3) | 6.3 (1.6-23.4) | 0.006* |
 | Negative (68) | 20 (20.9) | 48 (70.6) | Reference |  | 42 (61.8) | 26 (38.2) | Reference |  | 26 (38.2) | 42 (61.8) | Reference |  |
cagA?+?vacA-s2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (8) | 3 (37.5) | 5 (62.5) | 0.4 (0.1-2.2) | 0.337 | 5 (62.5) | 3 (37.5) | 0.9 (0.2-4.3) | 0.959 | 2 (25.0) | 6 (75.0) | 1.2 (0.2-6.5) | 0.810 |
 | Negative (91) | 19 (20.9) | 72 (79.1) | Reference |  | 55 (60.4) | 36 (39.6) | Reference |  | 27 (29.7) | 64 (70.3) | Reference |  |
cagA?+?vacA-s1?+?s2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Positive (7) | 2 (28.6) | 5 (71.4) | 0.9 (0.9-1.0) | 0.255 | 5 (71.4) | 2 (39.4) | 0.5 (0.1-3.2) | 0.537 | 1 (14.3) | 6 (85.7) | 2.7 (0.3-24.5) | 0.359 |
 | Negative (92) | 20 (21.7) | 72 (78.3) | Reference |  | 55 (59.8) | 37 (40.2) | Reference |  | 28 (30.4) | 64 (69.6) | Reference |  |