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Table 4 Correlation between interleukin-8 and H. pylori genotypes, chronic inflammation, neutrophil activity, and peptic ulcer disease

From: Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East

H. pylorigenotypea

Interleukin-8 levelb

p-valuec

Median (IQR)

 

cagA

  
  

Absent

1090.3 (1310.8)

0.011*

  

Present

1885.7 (1281.6)

 

vacA-s1

  
  

Absent

1245.8 (1550.2)

0.024*

  

Present

1840.0 (1098.6)

 

vacA-s2

  
  

Absent

1840.0 (1597.5)

0.004*

  

Present

965.6 (1205.1)

 

vacA-s1?+?s2

  
  

Absent

1541.1 (1566.3)

0.818

  

Present

1711.8 (1928.7)

 

cagA?+?vacA-s1

  
  

Absent

1311.8 (1814.9)

0.021*

  

Present

1901.7 (915.3)

 

cagA?+?vacA-s2

  
  

Absent

1577.5 (1548.6)

0.713

  

Present

1331.7 (?)

 

cagA?+?vacA s1?+?s2

  
  

Absent

1541.1 (1625.9)

0.807

  

Present

1711.8 (1803.6)

Histological findingsd

  
 

Chronic inflammation

  
  

None-Mild

689.2 (1420.6)

0.001*

  

Moderate-Marked

1835.7 (1345.3)

 

Neutrophil activity

  
  

None-Mild

1449.0 (1342.1)

0.007*

  

Moderate-Marked

1917.8 (2703.6)

Peptic ulcer

  
 

Absent

919.3 (1153.3)

0.001*

 

Present

1890.6 (1638.4)

  1. aAll patients were positive for either cagA, vacA or both.
  2. bpg/mg protein.
  3. cMann-Whitney U test.
  4. dAccording to the Updated Sydney system [40].
  5. *Statistically significant