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Figure 2 | Gut Pathogens

Figure 2

From: Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population

Figure 2

In vitro IL-8 production from AGS cells co-cultured with 6 ( dupA 1 + , cagA + , vacA + ) strains, 6 ( dupA 2 + , cagA + , vacA + ) and 6 ( dupA , cagA + , vacA + ) strains. IL-8 production was significantly higher in dupA1+ (cagA +, vacA +) compared to dupA2+ (cagA +, vacA +) (536.0 ± 100.4 pg/mL, P = 0.008) and dupA-negative strains (cagA +, vacA + ) (549.7 ± 104.1 pg/mL, P = 0.009). MOI of H. pylori strain was 100 for 8 hours. Experiments were repeated 3 times for the 18 strains. IL-8 in the supernatant was assayed by an ELISA in duplicate. Data are expressed as mean ± standard error.

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