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Fig. 1 | Gut Pathogens

Fig. 1

From: Core 2 mucin-type O-glycan inhibits EPEC or EHEC O157:H7 invasion into HT-29 epithelial cells

Fig. 1

Illustration of mucin-type O-glycan synthesis. Starting from N-acetylgalactosamine (GalNAc) on serine or threonine residues in a polypeptide, core 1 synthase (C1GnT) transfers galactose to make the Core 1 structure Galβ1 → 3GalNAcα1 → Ser/Thr, and core 3 synthase (C3GnT) transfers N-acetylglucosamine to form a core 3 structure GlcNAcβ1 → 3GalNAcα1 → Ser/Thr (Core 3). Core 1 is converted to Core 2 by C2GnT-1, C2GnT-2, and C2GnT-3. Core 3 is converted to Core 4 by C2GnT-2. Mannose, fucose, glucose and GlcNAc are directly linked to Ser/Thr, and they form core 5-8 structures

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