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Table 1 Clostridium difficile diagnostic test performances using enriched toxigenic culture as the reference standard

From: Comparison of a novel chemiluminescent based algorithm to three algorithmic approaches for the laboratory diagnosis of Clostridium difficile infection

  (%) Sensitivity (95% CI) (%) Specificity (95% CI) Positive predictive value (%) (95% CI) Negative predictive value (%) (95% CI)
DiaSorin algorithm = CLIA GDH + CLIA toxins A/B 86.7 (68.4–95.6) 99.1 (97.7–99.8) 86.7 (68.3–95.6) 98.1 (97.5–99.7)
Meridian algorithm = EIA GDH + NAAT for toxin gene 90.0 (72.3–97.8) 98.9 (97.4–99.5) 84.4 (66.5–94.1) 99.3 (97.8–99.8)
2-Step Alere algorithm = EIA GDH + EIA toxins A/B 50.0 (31.7–68.3) 99.5 (98.1–99.9) 88.2 (62.2–97.9) 96.7 (94.5–98.1)
3-Step Alere algorithm = EIA GDH + EIA toxins A/B + toxigenic culture 60.0 (40.7–76.7) 99.5 (98.1–99.9) 90.0 (66.8–98.2) 97.3 (95.2–98.5)
  1. CLIA chemiluminescence, GDH glutamate dehydrogenase, EIA enzyme immunoassay, NAAT nucleic acid amplification test, CI 95 % confidence interval