Skip to main content

Table 1 Clostridium difficile diagnostic test performances using enriched toxigenic culture as the reference standard

From: Comparison of a novel chemiluminescent based algorithm to three algorithmic approaches for the laboratory diagnosis of Clostridium difficile infection

 

(%) Sensitivity (95% CI)

(%) Specificity (95% CI)

Positive predictive value (%) (95% CI)

Negative predictive value (%) (95% CI)

DiaSorin algorithm = CLIA GDH + CLIA toxins A/B

86.7 (68.4–95.6)

99.1 (97.7–99.8)

86.7 (68.3–95.6)

98.1 (97.5–99.7)

Meridian algorithm = EIA GDH + NAAT for toxin gene

90.0 (72.3–97.8)

98.9 (97.4–99.5)

84.4 (66.5–94.1)

99.3 (97.8–99.8)

2-Step Alere algorithm = EIA GDH + EIA toxins A/B

50.0 (31.7–68.3)

99.5 (98.1–99.9)

88.2 (62.2–97.9)

96.7 (94.5–98.1)

3-Step Alere algorithm = EIA GDH + EIA toxins A/B + toxigenic culture

60.0 (40.7–76.7)

99.5 (98.1–99.9)

90.0 (66.8–98.2)

97.3 (95.2–98.5)

  1. CLIA chemiluminescence, GDH glutamate dehydrogenase, EIA enzyme immunoassay, NAAT nucleic acid amplification test, CI 95 % confidence interval