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Table 1 Comparison of fermentation related organism between “F. rodentium” ALO17 and other 4 references of A. stercoricanis DSM 13633T, H. biformis DSM 3989T, F. cylindroides ATCC 27803T and E. dolichum DSM3991T

From: Whole genome sequencing of “Faecalibaculum rodentium” ALO17, isolated from C57BL/6J laboratory mouse feces

Subsystem

Role description

Number of genes

Alo17

13633T

3989T

27803T

3991T

Butanol biosynthesis

Alcohol dehydrogenase (EC 1.1.1.1)

1

1

1

1

1

Butanol biosynthesis

NADH-dependent butanol dehydrogenase A (EC 1.1.1.-)

1

1

1

0

1

Butanol biosynthesis

Pyruvate formate-lyase (EC 2.3.1.54)

3

1

5

4

1

Butanol biosynthesis

3-Hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)

3

1

1

1

1

Butanol biosynthesis

Acetyl-CoA acetyltransferase (EC 2.3.1.9)

1

1

2

2

1

Fermentations: mixed acid

Alcohol dehydrogenase (EC 1.1.1.1)

1

1

1

1

1

Fermentations: mixed acid

l-lactate dehydrogenase (EC 1.1.1.27)

2

1

2

2

1

Fermentations: mixed acid

Sugar/maltose fermentation stimulation protein homolog

1

0

0

0

0

Fermentations: mixed acid

Pyruvate formate-lyase (EC 2.3.1.54)

3

1

5

4

1

Fermentations: mixed acid

Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)

3

1

4

4

1

Fermentations: mixed acid

Phosphate acetyltransferase (EC 2.3.1.8)

1

1

1

0

1

Fermentations: Mixed acid

Acetate kinase (EC 2.7.2.1)

1

1

1

1

1

Acetolactate synthase subunits

Acetolactate synthase large subunit (EC 2.2.1.6)

1

1

0

0

0

Acetolactate synthase subunits

Acetolactate synthase small subunit (EC 2.2.1.6)

1

1

0

0

0

Fermentations: lactate

l-Lactate dehydrogenase (EC 1.1.1.27)

2

1

2

2

1

Fermentations: lactate

Phosphate acetyltransferase (EC 2.3.1.8)

1

1

1

0

1

Fermentations: lactate

Acetate kinase (EC 2.7.2.1)

1

1

1

1

1

Acetyl-CoA fermentation to butyrate

3-Hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)

1

1

1

1

0

Acetyl-CoA fermentation to butyrate

Electron transfer flavoprotein, beta subunit

2

1

1

1

0

Acetyl-CoA fermentation to butyrate

Electron transfer flavoprotein, alpha subunit

2

1

1

1

0

Acetyl-CoA fermentation to butyrate

3-Hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)

3

1

1

1

0

Acetyl-CoA fermentation to butyrate

3-Hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)

3

1

1

1

0

Acetyl-CoA fermentation to butyrate

Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8)

1

1

2

1

0

Acetyl-CoA fermentation to butyrate

Acetyl-CoA Acetyltransferase (EC 2.3.1.9)

1

1

2

2

0