Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA

Nagy, Peter; Johansson, Saga; Molloy-Bland, Michael

doi:10.1186/s13099-016-0091-7

Gut Pathogens

Table 1 Characteristics of selected studies reporting the prevalence of Helicobacter pylori infection in mainland China

From: Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA

Reference	Location	Population	N	Age of study population, years	Women, %	Rural/urban	Test	Study midpoint	H. pylori infection, %
Studies with midpoints before the mean of all study midpoints
Forman et al. 1990 [16]	46 rural counties	General	1882	35‒64	50	Rural	Serum IgG	1983.75	60.4
			595	35–39					55.8
			913	40–49					56.6
			1061	50–59					65.8
			455	60–64					62.5
Yuan et al. 1999 [17]	Shanghai city	Healthy controls (cases had gastric cancer)	548	45‒64	NS	Urban	Serum IgG	1988	82
Zhang et al. 1996 [18]	14 randomly selected rural villages in Linqu County (Shandong province)	General (endoscopic survey)	2646	35‒64	47	Rural	Serum IgG	1989	72
Wang et al. 2008 [19]	67 rural counties	General	4020	35‒64; distributed equally across 10-year age groups	NS	Rural	Serum IgG	1989	71.4
Chen et al. 2003 [20]	Shanghai	Health check	668	≥20	38	Urban	Serum IgG	1990	44.5
			116	20–29					41.4
			132	30–39					46.2
			112	40–49					47.3
			104	50–59					50.0
			204	≥60					40.7
Chen et al. 2002 [21]	Shanghai	Health check	822	≥20	NS	Rural	Serum IgG	1990	62.0
			147	20–29					58.5
			182	30–39					64.3
			168	40–49					65.5
			121	50–59					68.6
			204	≥60					55.9
Chen et al. 2007 [22]	Guangzhou city	Health check	456	≥20	48	Urban	Serum IgG	1993	70.2
			135	20–29					65.2
			102	30–39					72.6
			109	40–49					76.2
You et al. 1998 [23]	Village in Cangshan County (Shandong province), which has a low incidence of gastric cancer	General	197	35‒64	50	Rural	Serum IgG	1994	55
Ma et al. 1998 [24]	Single village in Linqu County (Shandong province), which has a high incidence of gastric cancer	General (endoscopic survey)	289	35‒64	48	Rural	Serum IgG	1994	67.5
			131	35–44					77.3
			81	45–54					63.0
			77	55–64					62.3
Wong et al. 1999 [25]	Seven villages (Wuhong, Yingchen, Meihua, Xuojan, Yutien, Jiangtien, and Hunane) in Changle County, which has a high incidence of gastric cancer	Health check	1828	18–76 Mean: 43.0	NS	Rural	Serum IgG	1994.5	80.9
Cai et al. 2000 [26]	Changle County (Fujian province), which has a high incidence of gastric cancer	Healthy controls (cases had gastric cancer)	100	≥30	14	NS	Serum IgG	1997.25	68
			5	30–39					–
			18	40–49					–
			22	50–59					–
			38	60–69					–
			18	≥70					–
Brown et al. 2001 [27]	Linqu County (Shandong province)	General	3228	NS	63	Rural	Serum IgG	1998	60.6
			770	35–39					63.0
			848	40–44					62.5
			893	45–54					60.0
			299	55–59					57.0
			478	≥60					57.0
Studies with midpoints after the mean of all study midpoints
Chen et al. 2003 [20]	Shanghai	Health check	1272	≥20	37	Urban	Serum IgG	2001	65.4
			168	20–29					52.4
			251	30–39					60.6
			460	40–49					70.0
			151	50–59					72.8
			242	≥60					66.1
Chen et al. 2007 [22]	Guangzhou city	Health check	1001	≥20	NS	Urban	Serum IgG	2003.5	56.4
			253	20–29					53.4
			196	30–39					54.6
			204	40–49					63.2
			163	50–59					57.7
Cheng et al. 2009 [28]	Beijing	Health check	1161	≥20	47	Both	Breath test	2003.75	46.6
			46	20–29					41.3
			222	30–39					49.5
			397	40–49					45.6
			369	50–59					44.4
			94	≥60					53.2
Chen et al. 2008 [29]	Five regions of Zhejiang province	Cirrhotic patients	457	Mean: 57.3 SD: 13	26	NS	Biopsies (rapid urease test and histology)	2004.25	60.6
Shi et al. 2008 [30]	Three rural villages in Xiangshui and Gaoyou (Northern Jiangsu province)	General	1322	≥20	57	Rural	Serum IgG and breath test	2005	62.1
			48	20–30					56
			84	30–40					67.3
			287	40–50					57.6
			297	50–60					64.3
			372	>60					60.6
Zhang et al. 2009 [31]	Yanqing County (Beijing municipality), which has a low incidence of gastric cancer	General	503	40‒79	53	Rural	Stool antigen assay	2006.5	41.4
			178	40–49					37.1
			215	50–59					44.2
			110	60–79					42.7
Zhang et al. 2009 [31]	Muping County (Shandong province), which has a high incidence of gastric cancer	General	526	40‒79	53	Rural	Stool antigen assay	2006.5	51
			214	40–49					47.7
			208	50–59					53.4
			104	60–79					52.9
Peng et al. 2009 [32]	Guangzhou city	Health check	2580	≥18 Mean: 45.1 SD: 14.2	50	Urban	Breath test and biopsy	2006.75	28
Li et al. 2010 [33]	Five regions in Shanghai	General	3151	18–80 Mean: 47.7 SD: 14.1	56	Both	Serum IgG	2007.75	73.3
Wang et al. 2011 [34]	Shandong province	Health check	1637	Mean: 47	39	NS	Serum IgG	2008.75	35.5
Xia et al. 2012 [35]	Shijiazhuang city	Migrant workers	324	Mean: 37.8	59	Urban	Breath test	2009.5	41.0
			211	<40					44.1
			113	≥40					35.4
Wang et al. 2012 [36]	Xi’an, north-west China, which has a high incidence of gastric cancer	Healthy controls (cases had gastric cancer)	514	Mean: 58.2	27	NS	Serum IgG	2009.5	35
Jing Jiang et al. 2012 [37]	Jilin province	Healthy controls from routine health check (cases were patients with gastric cancer)	932	35–80	42	Both	Serum IgG	2009.5	49.7
Hu et al. 2012 [38]	Dalian Port	Health check (maritime workers)	3995	≥18	21	Urban	Serum IgG	2010.5	44.9
			945	18–29					43.1
			1245	30–39					41.2
			1111	40–49					50.1
Cao et al. 2014 [39]	Tianjin	Healthy controls (cases had fundic gland polyps)	530	NS	NS	Urban	Breath test, rapid urease test, or histology	2011.75	42.3
Xu et al. 2014 [40]	Zhejiang province	Health check	8820	Median: 46.0 Range: 39‒53	40	NS	Breath test	2013	43.8

IgG immunoglobulin G, NS not specified, SD standard deviation

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