Fig. 5

Role of H. pylori plasticity region in in vitro induction of IL-8. In vitro IL-8 production from AGS cells co-cultured with randomly selected cagA(+)vacA(+)P(+), cagA(−)vacA(-)P(+), and cagA(−)vacA(−)P(−) H. pylori strains (MOI is 100) for 8 h. IL-8 from culture supernatant was measured using ELISA as described in "Methods" section. Data are expressed as mean ± standard error of mean (SEM) of 3 experiments in duplicates. vacA positive and negative denote the vacA s1m1 and vacA s2m2 alleles, respectively