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Table 1 Minimum inhibitory concentration (MIC) values of antimicrobials against C. difficile strains

From: The efficacy of thuricin CD, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide, independently and in paired combinations against Clostridium difficile biofilms and planktonic cells

Antimicrobial/Strain

Teicoplanin nM (μg/ml)

Tigecycline nM (μg/ml)

Nitazoxanide nM (μg/ml)

Rifampicin nM (μg/ml)

Thuricin CDa nM (μg/ml)

Vancomycinb nM (μg/ml)

20291 R027

78 (0.146)

312 (0.183)

1560 (0.479)

8 (0.0064)

125 (0.703)

625 (0.928)

Liv022 R106

156 (0.292)

625 (0.366)

780 (0.239)

2 (0.0016)

250 (1.406)

1250 (1.856)

TL178 R002

156 (0.292)

625 (0.366)

390 (0.120)

2 (0.0016)

500 (2.812)

625 (0.928)

DPC6350

156 (0.292)

156 (0.091)

1560 (0.479)

2 (0.0016)

125 (0.703)

625 (0.928)

VPI10463

78 (0.146)

156 (0.091)

780 (0.239)

2 (0.0016)

125 (0.703)

312 (0.464)

  1. MICs of various antimicrobials against planktonic cells of C. difficile strains expressed in nanomolar concentrations and also in μg/ml in parentheses and in italics
  2. The MICs of thuricin CDa and vancomycinb against strains 20291 R027, Liv022 R106 and TL178 R002 were already determined and reported in our previous study [7]