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Fig. 7 | Gut Pathogens

Fig. 7

From: The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection

Fig. 7

TNF secretion in colonic ex vivo biopsies derived from C. jejuni infected mice lacking IL-23p19, IL-22 or IL-18. Conventional wildtype (WT), IL-23p19−/−, IL-22−/− and IL-18−/− mice were perorally infected with C. jejuni strain ATCC 43431 by gavage at days 0, 1 and 2. TNF concentrations were determined in supernatants of colonic ex vivo biopsies derived at day (d) 14 (black circles) postinfection. Naive (N) mice served as uninfected controls (white circles). Medians (black bars), levels of significance (p values) determined by Mann–Whitney U test, and numbers of analyzed animals (in parentheses) are indicated. Data were pooled from three independent experiments

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