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Fig. 7 | Gut Pathogens

Fig. 7

From: Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA

Fig. 7

Model of calcium-regulated HpHtrA-mediated cleavage of E-cadherin. The extracellular N-terminal part of E-cadherin is shown with the identified signature sites (open arrows) between the five EC domains (EC1-EC5) and an additional cleavage site in the linker region (black arrow) for HpHtrA. Signature sites can be bound by calcium ions (red spheres) leading to conformational changes in the E-cadherin molecule, which allow homophilic interactions of E-cadherin in cis and trans. HtrA-mediated E-cadherin cleavage can be inhibited after binding of calcium ions to the signature sites, either by blocking the accessibility of signature sites for HpHtrA or by changing of the conformational structure of E-cadherin

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