Table 1 In-vitro activity of RHB-104 and its individual active ingredients against clinical Mycobacterium strains
Microorganism | Minimum inhibitory concentration (μg/mL) | |||
|---|---|---|---|---|
CLA | CLO | RIF | CLA–CLO–RIF | |
Clinical MAP strains | ||||
MAP UCF 3 | 0.25 | 1 | 0.5 | 0.25 |
MAP UCF 4 | 0.25 | 0.5 | 0.5 | 0.25 |
MAP UCF 5 | 0.25 | 0.5 | 0.5 | 0.25 |
MAP UCF 7 | 1 | 0.5 | 0.5 | 0.25 |
MAP UCF 8 | 1 | 0.5 | 0.5 | 0.25 |
MAP UCF 10 | 10 | >10 | >10 | 10 |
MAP Strain 1 | 1 | 1 | 1 | 0.25 |
MAP Strain 3 | 1 | 1 | 1 | 0.25 |
MAP Strain 7 | 1 | 1 | 1 | 0.25 |
MAP Strain 8B | 1 | 1 | 1 | 0.25 |
MAP MS 137 | 4 | 4 | >6 | 4 |
MAP MS 185 | 4 | 6 | >6 | 4 |
MAP Para 18 | 1 | >1 | >1 | 0.25 |
MAP Ben | 1 | >1 | 1 | 0.25 |
MAP Kay | 0.5 | 1 | 2 | 0.25 |
MAP Linda | 0.5 | 2 | 0.5 | 0.25 |
Non-MAP strains | ||||
M. avium | 4 | >6 | >6 | 4 |
M. avium NEZ | >1 | >1 | >1 | >1 |
M. avium JF1 | >20 | >20 | >20 | >20 |
M. avium JF2 | >6 | >6 | >6 | >4 |
M. avium JF3 | >6 | >6 | >6 | >4 |
M. avium JF4 | >6 | >6 | >6 | >4 |
M. avium JF5 | >6 | >6 | >6 | 4 |
M. avium JF6 | >6 | >6 | >6 | 4 |
M. avium JF 7 | >6 | >6 | >6 | >4 |
M. avium JF8 | >6 | >6 | >6 | 4 |
M. intracellulare LM1-A | >6 | >6 | >6 | 4 |
M. smegmatis | >6 | >6 | >6 | 6 |
M. chelonae | >10 | 10 | >10 | >10 |
M. fortuitum | >10 | >10 | >10 | >10 |
M. scrofulaceum | 10 | 10 | 10 | 10 |
M. terrae | 10 | 10 | 10 | 10 |
M. tuberculosis | 10 | 10 | 10 | 10 |
M. xenopi | 10 | 10 | 10 | 10 |
M. vallae | 10 | 10 | 10 | 10 |