Table 3 Virulence genes of KP617 and the reference strains
Strains | Category | Subcategory | Name |
|---|---|---|---|
KP617, PittNDM01, NUHL24385 and ATCC BAA-2146 | Acid resistance | Urease | ureA, ureB, ureF, ureG, ureH |
Adherence | Cell wall associated fibronectin binding protein | ebh | |
Adherence | CFA/I fimbriae | ibeB | |
Adherence | Flagella | fleN, fleR, fleS | |
Adherence | Hsp60 | htpB | |
Adherence | Intercellular adhesin | icaA, icaR | |
Adherence | Listeria adhesion protein | lap | |
Adherence | OapA | oapA | |
Adherence | Omp89 | omp89 | |
Adherence | P fimbriae | papX | |
Adherence | PEB1/CBF1 | pebA | |
Adherence | Phosphoethanolamine modification | lptA | |
Adherence | Type I fimbriae | fimB, fimE, fimG | |
Adherence | Type IV pili | comE/pilQ | |
Adherence | Type IV pili biosynthesis | pilM, pilW | |
Adherence | Type IV pili twitching motility related proteins | chpD, chpE | |
Adhesin | Laminin-binding protein | lmb | |
Adhesin | Streptococcal lipoprotein rotamase A | slrA | |
Adhesin | Streptococcal plasmin receptor/GAPDH | plr/gapA | |
Adhesin | Type IV pili | pilD, pilN, pilR, pilR, pilS, pilT | |
Amino acid and purine metabolism | Glutamine synthesis | glnA1 | |
Amino acid and purine metabolism | Leucine synthesis | leuD | |
Amino acid and purine metabolism | Lysine synthesis | lysA | |
Amino acid and purine metabolism | Proline synthesis | proC | |
Amino acid and purine metabolism | Purine synthesis | purC | |
Amino acid and purine metabolism | Tryptophan synthesis | trpD | |
Anaerobic respiration | Nitrate reductase | narG, narH, narI, narJ | |
Anaerobic respiration | Nitrate/nitrite transporter | narK2 | |
Anti-apoptosis factor | NuoG | nuoG | |
Antimicrobial activity | Phenazines biosynthesis | phzE1, phzF1, phzG1phzS | |
Antiphagocytosis | Alginate regulation | algQ, algR, algU, algW, algZ, mucB, mucC, mucD, mucP | |
Antiphagocytosis | Capsular polysaccharide | cpsB, wbfT, wbfV/wcvB, wbjD/wecB, wza, wzc | |
Antiphagocytosis | Capsule | cpsF | |
Antiphagocytosis | Capsule I | gmhA, wcbN, wcbP, wcbR, wcbT, wzt2 | |
Cell surface components | GPL locus | fadE5, fmt, rmlB | |
Cell surface components | MymA operon | adhD, fadD13, sadH, tgs4 | |
Cell surface components | PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport | ddrA, mas, ppsC, ppsE | |
Cell surface components | Potassium/proton antiporter | kefB | |
Cell surface components | Proximal cyclopropane synthase of alpha mycolates | pcaA | |
Cell surface components | Trehalose-recycling ABC transporter | lpqY, sugA, sugB, sugC | |
Chemotaxis and motility | Flagella | flrA, flrB | |
Efflux pump | FarAB | farA, farB | |
Efflux pump | MtrCDE | mtrC, mtrD | |
Endotoxin | LOS | gmhA/lpcA, kdtA, kpsF, lgtF, licA, lpxH, msbA, opsX/rfaC, orfM, rfaD, rfaE, rfaF, wecA, yhbX | |
Endotoxin | LPS | bplA, bplC, bplF, wbmE, wbmI | |
Endotoxin | LPS-modifying enzyme | pagP | |
Exoenzyme | Cysteine protease | sspB | |
Exoenzyme | Streptococcal enolase | eno | |
Fimbrial adherence determinants | Agf/Csg | csgD | |
Fimbrial adherence determinants | Fim | fimA, fimC, fimD, fimF, fimH, fimI | |
Fimbrial adherence determinants | Lpf | lpfB, lpfC | |
Fimbrial adherence determinants | Stg | stgA | |
Fimbrial adherence determinants | Sth | sthA, sthB, sthC, sthD, sthE | |
Fimbrial adherence determinants | Sti | stiB | |
Glycosylation system | N-linked protein glycosylation | pglJ | |
Host immune evasion | Exopolysaccharide | galE, galU, manA, mrsA/glmM, pgi | |
Host immune evasion | LPS glucosylation | gtrB | |
Host immune evasion | Polyglutamic acid capsule | capD | |
Immune evasion | LPS | acpXL, htrB, kdsA, lpxA, lpxB, lpxC, lpxD, lpxK, pgm, wbkC | |
Intracellular survival | LigA | ligA | |
Intracellular survival | Lipoate protein ligase A1 | lplA1 | |
Intracellular survival | Mip | mip | |
Intracellular survival | Oligopeptide-binding protein | oppA | |
Intracellular survival | Post-translocation chaperone | prsA2 | |
Intracellular survival | Sugar-uptake system | hpt | |
Invasion | Ail | ail | |
Invasion | Cell wall hydrolase | iap/cwhA | |
Iron acquisition | Cytochrome c muturation (ccm) locus | ccmA, ccmB, ccmC, ccmE, ccmF | |
Iron acquisition | Ferrous iron transport | feoA, feoB | |
Iron acquisition | Iron acquisition/assimilation locus | iraB | |
Iron and heme acquisition | Haemophilus iron transport locus | hitA, hitB, hitC | |
Iron and heme acquisition | Heme biosynthesis | hemA, hemB, hemC, hemD, hemE, hemG, hemH, hemL, hemM, hemN, hemX, hemY | |
Iron uptake | ABC transporter | fagD | |
Iron uptake | ABC-type heme transporter | hmuT, hmuU, hmuV | |
Iron uptake | Achromobactin biosynthesis and transport | acsB, cbrB, cbrD | |
Iron uptake | Aerobactin transport | iutA | |
Iron uptake | ciu iron uptake and siderophore biosynthesis system | ciuD | |
Iron uptake | Enterobactin receptors | irgA | |
Iron uptake | Enterobactin synthesis | entE, entF | |
Iron uptake | Enterobactin transport | fepA, fepB, fepC, fepD, fepG | |
Iron uptake | Heme transport | shuV | |
Iron uptake | Hemin uptake | chuS, chuT, chuY | |
Iron uptake | Iron-regulated element | ireA | |
Iron uptake | Iron/managanease transport | sitA, sitB, sitC, sitD | |
Iron uptake | Periplasmic binding protein-dependent ABC transport systems | viuC | |
Iron uptake | Pyochelin | pchA, pchB, pchR | |
Iron uptake | Pyoverdine | pvdE, pvdH, pvdJ, pvdM, pvdN, pvdO | |
Iron uptake | Salmochelin synthesis and transport | iroE, iroN | |
Iron uptake | Vibriobactin biosynthesis | vibB | |
Iron uptake | Vibriobactin utilization | viuB | |
Iron uptake | Yersiniabactin siderophore | ybtA, ybtP | |
Iron uptake systems | Ton system | exbB, exbD | |
Lipid and fatty acid metabolism | FAS-II | kasB | |
Lipid and fatty acid metabolism | Isocitrate lyase | icl | |
Lipid and fatty acid metabolism | Pantothenate synthesis | panC, panD | |
Lipid and fatty acid metabolism | Phospholipases C | plcD | |
Macrophage inducible genes | Mig-5 | mig-5 | |
Magnesium uptake | Mg2+ transport | mgtB | |
Mammalian cell entry (mce) operons | Mce3 | mce3B | |
Metal exporters | Copper exporter | ctpV | |
Metal uptake | ABC transporter | irtB | |
Metal uptake | Exochelin (smegmatis) | fxbA | |
Metal uptake | Heme uptake | mmpL11 | |
Metal uptake | Magnesium transport | mgtC | |
Metal uptake | Mycobactin | fadE14, mbtH, mbtI | |
Motility and export apparatus | Flagella | flhF, flhG, fliY | |
Nonfimbrial adherence determinants | SinH | sinH | |
Other adhesion-related proteins | EF-Tu | tuf | |
Other adhesion-related proteins | PDH-B | pdhB | |
Others | MsbB2 | msbB2 | |
Others | Nuclease | nuc | |
Others | VirK | virK | |
Phagosome arresting | Nucleoside diphosphate kinase | ndk | |
Protease | Trigger factor | tig/ropA | |
Proteases | Proteasome-associated proteins | mpa | |
Quorum sensing | Autoinducer-2 | luxS | |
Quorum sensing systems | Acylhomoserine lactone synthase | hdtS | |
Quorum sensing systems | N-(butanoyl)-l-homoserine lactone QS system | rhlR | |
Regulation | Alternative sigma factor RpoS | rpoS | |
Regulation | AtxA | atxA | |
Regulation | BvrRS | bvrR | |
Regulation | Carbon storage regulator A | csrA | |
Regulation | DevR/S | devR/dosR | |
Regulation | GacS/GacA two-component system | gacA, gacS | |
Regulation | LetA/LetS two component | letA | |
Regulation | LisR/LisK | lisK | |
Regulation | MprA/B | mprA, mprB | |
Regulation | PhoP/R | phoR | |
Regulation | RegX3 | regX3 | |
Regulation | RelA | relA | |
Regulation | SenX3 | senX3 | |
Regulation | Sigma A | sigA/rpoV | |
Regulation | Two-component system | bvgA, bvgS | |
Secreted proteins | Antigen 85 complex | fbpB, fbpC | |
Secretion system | Accessory secretion factor | secA2 | |
Secretion system | Bsa T3SS | bprC | |
Secretion system | Flagella (cluster I) | fliZ | |
Secretion system | Mxi-Spa TTSS effectors controlled by MxiE | ipaH, ipaH2.5 | |
Secretion system | P. aeruginosa TTSS | exsA | |
Secretion system | P. syringae TTSS | hrcN | |
Secretion system | P. syringae TTSS effectors | hopAJ2, hopAN1, hopI1 | |
Secretion system | TTSS secreted proteins | bopD | |
Secretion system | Type III secretion system | bscS | |
Secretion system | Type VII secretion system | essC | |
Secretion system | VirB/VirD4 type IV secretion system & translocated effector Beps | bepA | |
Serum resistance | BrkAB system | brkB | |
Stress adaptation | AhpC | ahpC | |
Stress adaptation | Catalase-peroxidase | katG | |
Stress adaptation | Pore-forming protein | ompA | |
Stress protein | Catalase | katA | |
Stress protein | Manganese transport system | mntA, mntB, mntC | |
Stress protein | Recombinational repair protein | recN | |
Stress protein | SodCI | sodCI | |
Surface protein anchoring | Lipoprotein diacylglyceryl transferase | lgt | |
Surface protein anchoring | Lipoprotein-specific signal peptidase II | lspA | |
Toxin | Beta-hemolysin/cytolysin | cylG | |
Toxin | Enterotoxin | entA, entB, entC, entD | |
Toxin | Hydrogen cyanide production | hcnC | |
Toxin | Phytotoxin phaseolotoxin | argD, argK, cysC1 | |
Toxin | Streptolysin S | sagA | |
Toxins | Alpha-hemolysin | hlyA | |
Toxins | Enterotoxin SenB/TieB | senB | |
Two-component system | PhoPQ | phoP, phoQ | |
Type I secretion system | ABC transporter for dispersin | aatC | |
KP617, PittNDM01 and NUHL24385 | Antiphagocytosis | Capsular polysaccharide | cpsA |
Cell surface components | GPL locus | pks | |
Cell surface components | Mycolic acid trans-cyclopropane synthetase | cmaA2 | |
Endotoxin | LOS | lgtA | |
Iron uptake | Pyoverdine receptors | fpvA | |
Iron uptake | Vibriobactin biosynthesis | vibA | |
Iron uptake | Yersiniabactin siderophore | irp1, irp2, ybtE, ybtQ, ybtS, ybtT, ybtU, ybtX | |
Secretion system | EPS type II secretion system | epsG | |
Secretion system | Trw type IV secretion system | trwE | |
Secretion system | VirB/VirD4 type IV secretion system & translocated effector Beps | virB11, virB4, virB9 | |
Toxin | RTX toxin | rtxB, rtxD | |
KP617 and PittNDM01 | Adhesin | Streptococcal collagen-like proteins | sclB |
Chemotaxis and motility | Flagella | flrC | |
Iron uptake | Yersiniabactin siderophore | fyuA |