TY - JOUR AU - Han, Zifeng AU - Willer, Thomas AU - Pielsticker, Colin AU - Gerzova, Lenka AU - Rychlik, Ivan AU - Rautenschlein, Silke PY - 2016 DA - 2016/11/10 TI - Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken JO - Gut Pathogens SP - 56 VL - 8 IS - 1 AB - Chickens are regarded as the main reservoir for human campylobacteriosis. Little is known about the interaction between Campylobacter jejuni (C. jejuni) and chickens. This interaction may be influenced by the stage of maturation of the immune system, developing gut microbiota composition and other factors including breed and diet. Our aim was to investigate the impact of breed, and diet on C. jejuni colonization and host immune responses in chickens. Birds were inoculated with 104 colony forming units (CFU) of C. jejuni or diluent at one (Exp. 1) or 22 (Exp. 2) days post hatch. We compared local immune cell subpopulations, cytokine expression levels, and gut microbiota composition between broiler-type (BT) and layer-type (LT) birds fed with either commercial broiler feed (bf) or layer feed (lf). SN - 1757-4749 UR - https://doi.org/10.1186/s13099-016-0133-1 DO - 10.1186/s13099-016-0133-1 ID - Han2016 ER -