Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes

Table 2 The number of CagL variants in GC and non-GC isolates

Residue	Reference	Variant	GC (n = 10)	(%)	non-GC (n = 30)	(%)	p value (GC versus non-GC)
4	Leu	Phe	1	10	2	6.7	NS
19	Met	Va1	1	10	0	0	NS
28	Lys	Arg	0	0	2	6.7	NS
32	Ser	Arg	0	0	2	6.7	NS
32	Ser	Asn	2	20	0	0	NS
35	Gln	Lys	10	100	29	96.7	NS
41	Val	Ala	2	20	0	0	NS
54	Pro	Ser	0	0	1	3.3	NS
58	Asn	Asp	8	80	30	100	NS
58	Asn	Tyr	1	10	0	0	NS
59	Glu	Lys	2	20	25	83.3	0.001
59	Glu	Asn	1	10	1	3.3	NS
60	Met	Ile	9	90	30	100	NS
60	Met	Thr	1	10	0	0	NS
62	Glu	Lys	8	80	30	100	NS
62	Glu	Gln	1	10	0	0	NS
65	Ala	Ser	0	0	6	20	NS
78	Asp	Asn	0	0	1	3.3	NS
88	Ala	Thr	3	30	0	0	<0.05
98	Val	Met	0	0	2	6.7	NS
101	Lys	Asn	3	30	0	0	<0.05
108	Glu	Asp	1	10	1	3.3	NS
122	Asn	Lys	9	90	28	93.3	NS
122	Asn	Glu	0	0	1	3.3	NS
141	Gly	Ala	5	50	0	0	<0.001
142	Lys	Glu	5	50	0	0	<0.001
144	Lys	Gln	1	10	0	0	NS
154	Glu	Asp	0	0	2	6.7	NS
158	Thr	Ala	1	10	1	3.3	NS
162	Ala	Thr	0	0	1	3.3	NS
167	Ile	Val	0	0	1	3.3	NS
171	Ala	Thr	0	0	1	3.3	NS
181	Val	Ile	2	20	0	0	NS
201	Asn	Asp	3	30	24	80	<0.05
203	Val	Ile	1	10	3	10	NS
210	Glu	Lys	8	80	27	90	NS
216	Arg	Ile	10	100	28	93.3	NS
221	Ser	Asn	2	20	4	13.3	NS
223	Arg	Gln	0	0	1	3.3	NS
234	Ile	Val	3	30	23	76.7	<0.05

Statistical analysis was performed by Fisher’s exact test. Residue 234 is a part of the C-terminal motif in the distal six amino acids of CagL
GC gastric cancer, NS not significant

ISSN: 1757-4749