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Table 2 H. pylori infection, status of cagA/babA2 and vacA genotypes in patients with gastric pathology

From: Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico

  Diagnosis p value
CG n (%) GU n (%) GC n (%)
H. pylori
 Negative 400 (52.2) 58 (50.4) 15 (38.5) 0.243Ф
 Positive 367 (47.8) 57 (49.6) 24 (61.5)
 Total 767 (100) 115 (100) 39 (100)
Distribution of H. pylori by age group
 ≤20 years old 16 (4.4) 1 (1.8) 0 0.003δ
 20–39 years old 120 (32.7) 10 (17.5) 4 (16.7)
 40–59 years old 162 (44.1) 26 (45.6) 8 (33.3)
 ≥60 years old 69 (18.8) 20 (35.1) 12 (50)
Total 367 (100) 57(100) 24 (100)
vacA alleles
 s1 290 (83.3) 49 (84.5) 21(91.3)  
 s2 58 (16.7) 9 (15.5) 2 (8.7)  
 m1 201 (60.9) 36 (67.9) 20 (90.9)  
 m2 129 (39.1) 17 (32.1) 2 (9.1)  
vacA genotypes
 s1m1 166 (45.2) 35 (61.4) 20 (83.3) 0.017δ
 s1m2 62 (16.8) 7 (12.2) 0
 s2m1 9 (2.5) 0 0
 s2m2 41 (11.2) 9 (15.8) 2 (8.3)
 s1m1/s1m2 22 (6) 1 (1.8) 0
 s2m1/s2m2 4 (1.1) 0 0
 s1m0 18 (4.9) 5 (8.8) 1 (4.2)
 s0m2 4 (1.1) 0 0
 Non-typeable 41 (11.2) 0 1 (4.2)
 Total 367 (100) 57 (100) 24 (100)
cagA
 Negative 158 (43.0) 22 (38.6) 10 (41.7) 0.925Ф
 Positive 209 (57.0) 35 (61.4) 14 (58.3)
 Total 367 (100) 57 (100) 24 (100)
babA2
 Negative 268 (73.0) 42 (73.7) 14 (58.3) 0.114Ф
 Positive 99 (27.0) 15 (26.3) 10 (41.7)
 Total 367 (100) 57 (100) 24 (100)
vacA/cagA genotypes a
 s2m2/cagA 26 (14.1) 3 (7.9) 1 (6.3) 0.114δ
 s2m2/cagA+ 7 (3.8) 2 (5.3) 0
 s1m1/cagA 21 (11.4) 11 (28.9) 2 (12.5)
 s1m1/cagA+ 130 (70.7) 22 (57.9) 13 (81.3)
 Total 184 (100) 38 (100) 16 (100)
  1. CG chronic gastritis, GU gastric ulcer, GC gastric cancer
  2. Ф X2 test, δ Exact Fisher test; s0: non-typeable for signal region. m0: non-typeable for middle region
  3. aIn this analysis only were included the infections caused by one vacA genotype