Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens

Mathipa, Moloko Gloria; Thantsha, Mapitsi Silvester

doi:10.1186/s13099-017-0178-9

Gut Pathogens

Table 1 Mechanisms of action of probiotics

From: Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens

Mechanism of action	Probiotic bacteria	Pathogen	Functionality	References
Competitive exclusion	L. acidophilus; L. johnsonii	S. enterica serovar Typhimurium, Enteropathogenic E. coli (EPEC), Yersinia pseudotuberculosis, L. monocytogenes	Inhibited adherence of pathogens to Caco-2 cells	[33]
	L. casei subsp. rhamnosus	EPEC, Enterotoxigenic E. coli (ETEC), Klebsiella pneumoniae	Inhibited adherence of pathogens to Caco-2 cells	[33]
	L. rhamnosus; L. acidophilus	E. coli O157:H7	Inhibited adherence of pathogens to T-84 epithelial cell; inhibited colonization to Caco-2 cells	[33, 51]
	L. acidophilus	H. pylori	Production of lacticins A164 and BH5	[37]
Production of inhibitory substances	L. lactis	E. coli, Salmonella	Production of alyteserin-1a and A3APO	[31]
	B. longum	Clostridium difficile, E. coli	Production of bacteriocin	[35]
	L. salivarius	L. monocytogenes	Production of bacteriocin Abp118	[35]
	L. sake	L. monocytogenes	Production of bacteriocin sakacin A	[39]
	L. plantarum	L. monocytogenes	Production of bacteriocins (plantaricins)	[40]
	L. lactis	C. difficile	Production of lacticin 3147	[45]
	L. lactis, L. casei, L. acidophilus	E. coli O157:H7	Reduced the growth of pathogen by lactic acid production and pH reductive effect	[33]
Immune system modulation	L. reuteri	Salmonella	Increased the production anti-Salmonella IgM	[35]
	L. rhamnosus	E. coli O157:H7	Increased intestinal anti-E. coli IgA responses and blood leukocyte phagocytic activity	[33]
	L. acidophilus, L. rhamnosus GG, L. johnsonii La1	S. Typhimurium	Increased the production of anti-Salmonella IgA	[42, 43]
Improved barrier function	L. plantarum, L. rhamnosus GG	E. coli O157:H7	Subvert the adherence of pathogen by increasing MUC2 and MUC3 in HT-29 epithelial cell line	[45, 47]
	L. acidophilus	E. coli	Protected against F-actin rearrangement, which was induced in an epithelial cell line on exposure to a pathogenic E. coli	[45]
	S. thermophilus; L. acidophilus	Enteroinvasive E. coli (EIEC)	Increased transepithelial resistance, maintenance and enhancement of cytoskeletal and tight junctional protein phosphorylation in HT29 and Caco-2 cell lines	[60]

Back to article page

ISSN: 1757-4749

Contact us

Submission enquiries: journalsubmissions@springernature.com