Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains

Peng, Zhong; Liu, Sidi; Meng, Xiujuan; Liang, Wan; Xu, Zhuofei; Tang, Biao; Wang, Yuanguo; Duan, Juping; Fu, Chenchao; Wu, Bin; Wu, Anhua; Li, Chunhui

doi:10.1186/s13099-017-0191-z

Gut Pathogens

Table 2 Antibiotic resistance associated proteins predicted in the ST201 genomes

From: Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains

Locus in LC693	Locus in VL-0104	Locus in VL-0391	Length (aa)	Description	Resistance	Presence in R20291	Presence in M120
0042	2926	1001	196	Virginiamycin A acetyltransferase, which can inactivate the target drug	Streptogramin_a	+	+
0115	2999	1075	197	Virginiamycin A acetyltransferase, which can inactivate the target drug	Streptogramin_a	+	−
0120	3004	1080	241	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	+
0267	3195	1228	65	Major facilitator superfamily transporter. Multidrug resistance efflux pump	Deoxycholate; fosfomycin	−	+
0402	3309	1347	228	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
0410	3317	1355	228	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
0412	3319	1357	223	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	+
0416	3323	1361	221	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide1094	+	+
0576	3486	1519	222	VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Vancomycin	+	+
0580	3490	1523	607	Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline	Tetracycline	+	+
0601	3511	1544	67	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
0699	3617	1658	210	Virginiamycin A acetyltransferase, which can inactivate the target drug	Streptogramin_a	+	+
0805	3681	1722	230	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
0820	3697	1738	238	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
1054	0094	1967	227	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
1094	0134	2007	238	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
1247	0352	2230	234	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	+
1500	0582	2467	283	Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate	Bacitracin	+	+
1568	0651	2535	250	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
1685	0767	−	238	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	−	−
1799	0854	2700	110	ABC transporter system, bacitracin efflux pump	Bacitracin	−	−
1869	0925	3336	371	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	−
1870	0926	3337	232	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	−
1962	1044	2900	276	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	−
2234	1252	3136	228	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
2251	1268	3166	230	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
2272	1289	3187	288	Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones	Fluoroquinolone	+	+
2466	1548	3530	305	ABC transporter system, bacitracin efflux pump	Bacitracin	+	+
2642	1673	3662	227	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
2655	1998	3676	234	ABC transporter system, bacitracin efflux pump	Bacitracin	+	+
2658	1995	3679	230	VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate	Teicoplanin; vancomycin	+	+
2661	1992	3682	222	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
2663	1990	3684	224	VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine	Vancomycin	+	+
2831	1853	0043	304	ABC transporter system, bacitracin efflux pump	Bacitracin	+	+
2922	2024	0104	192	Virginiamycin A acetyltransferase, which can inactivate the target drug	Streptogramin_a	−	+
3194	2245	0335	227	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
3599	2639	0706	274	Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate	Bacitracin	+	+
3614	2654	0729	235	ABC transporter system, bacitracin efflux pump	Bacitracin	+	+
3781	2789	0865	225	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
3846	2855	0930	224	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	+	+
−	−	1192	71	Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system	Macrolide	−	−
−	−	3284	174	VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine–d-serine	Vancomycin	−	−

“+” indicates corresponding genes present; “−” indicates no corresponding genes

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ISSN: 1757-4749

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