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Table 2 Antibiotic resistance associated proteins predicted in the ST201 genomes

From: Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains

Locus in LC693 Locus in VL-0104 Locus in VL-0391 Length (aa) Description Resistance Presence in R20291 Presence in M120
0042 2926 1001 196 Virginiamycin A acetyltransferase, which can inactivate the target drug Streptogramin_a + +
0115 2999 1075 197 Virginiamycin A acetyltransferase, which can inactivate the target drug Streptogramin_a +
0120 3004 1080 241 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin + +
0267 3195 1228 65 Major facilitator superfamily transporter. Multidrug resistance efflux pump Deoxycholate; fosfomycin +
0402 3309 1347 228 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
0410 3317 1355 228 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
0412 3319 1357 223 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin + +
0416 3323 1361 221 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide1094 + +
0576 3486 1519 222 VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Vancomycin + +
0580 3490 1523 607 Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline Tetracycline + +
0601 3511 1544 67 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
0699 3617 1658 210 Virginiamycin A acetyltransferase, which can inactivate the target drug Streptogramin_a + +
0805 3681 1722 230 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
0820 3697 1738 238 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
1054 0094 1967 227 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
1094 0134 2007 238 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
1247 0352 2230 234 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin + +
1500 0582 2467 283 Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate Bacitracin + +
1568 0651 2535 250 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
1685 0767 238 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin
1799 0854 2700 110 ABC transporter system, bacitracin efflux pump Bacitracin
1869 0925 3336 371 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin +
1870 0926 3337 232 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin +
1962 1044 2900 276 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin +
2234 1252 3136 228 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
2251 1268 3166 230 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
2272 1289 3187 288 Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones Fluoroquinolone + +
2466 1548 3530 305 ABC transporter system, bacitracin efflux pump Bacitracin + +
2642 1673 3662 227 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
2655 1998 3676 234 ABC transporter system, bacitracin efflux pump Bacitracin + +
2658 1995 3679 230 VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-lactate Teicoplanin; vancomycin + +
2661 1992 3682 222 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
2663 1990 3684 224 VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine-d-serine Vancomycin + +
2831 1853 0043 304 ABC transporter system, bacitracin efflux pump Bacitracin + +
2922 2024 0104 192 Virginiamycin A acetyltransferase, which can inactivate the target drug Streptogramin_a +
3194 2245 0335 227 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
3599 2639 0706 274 Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate Bacitracin + +
3614 2654 0729 235 ABC transporter system, bacitracin efflux pump Bacitracin + +
3781 2789 0865 225 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
3846 2855 0930 224 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide + +
1192 71 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system Macrolide
3284 174 VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal d-Ala-d-Ala to d-alanine–d-serine Vancomycin
  1. “+” indicates corresponding genes present; “−” indicates no corresponding genes