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Table 3 Distribution of genes (gyrA, 23S) in accordance with MIC breakpoints for fluoroquinolone and clarithromycin antibiotics

From: Phenotypic and genotypic correlation as expressed in Helicobacter pylori resistance to clarithromycin and fluoroquinolones

Gene

No. of samples

MIC range (μg/mL)

<0.125

0.19–0.25

0.38–0.5

0.75–1

1.5–2

3

>4

gyrA87 and gyrA91 genes

 Children

  WT

23

3

2

18

    

  N87K

5

1

1

2

1

   

  D91N

4

1

1

1

1

   

  D91G

4

1

1

1

1

   

  D91Y

0

       

 Adults

  WT

17

5

2

10

    

  N87K

4

3

 

1

    

  D91N

4

2

 

2

    

  D91G

4

2

1

1

    

  D91Y

2

1

1

     

23S rRNA (rrl) genes

 Children

  WT

9

 

2

2

2

1

2

 

  A2142G

0

       

  A2142C

2

  

1

1

   

  A2143G

19

2

1

5

1

5

4

1

 Adults

  WT

7

1

 

1

 

1

2

2

  A2142G

0

       

  A2142C

2

     

1

1

  A2143G

18

2

 

3

 

6

3

4

  1. More than one gene was present in several samples
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Gut Pathogens

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