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Table 3 Distribution of genes (gyrA, 23S) in accordance with MIC breakpoints for fluoroquinolone and clarithromycin antibiotics

From: Phenotypic and genotypic correlation as expressed in Helicobacter pylori resistance to clarithromycin and fluoroquinolones

Gene No. of samples MIC range (μg/mL)
<0.125 0.19–0.25 0.38–0.5 0.75–1 1.5–2 3 >4
gyrA87 and gyrA91 genes
 Children
  WT 23 3 2 18     
  N87K 5 1 1 2 1    
  D91N 4 1 1 1 1    
  D91G 4 1 1 1 1    
  D91Y 0        
 Adults
  WT 17 5 2 10     
  N87K 4 3   1     
  D91N 4 2   2     
  D91G 4 2 1 1     
  D91Y 2 1 1      
23S rRNA (rrl) genes
 Children
  WT 9   2 2 2 1 2  
  A2142G 0        
  A2142C 2    1 1    
  A2143G 19 2 1 5 1 5 4 1
 Adults
  WT 7 1   1   1 2 2
  A2142G 0        
  A2142C 2       1 1
  A2143G 18 2   3   6 3 4
  1. More than one gene was present in several samples