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Fig. 1 | Gut Pathogens

Fig. 1

From: Toll-like receptor-4 differentially mediates intestinal and extra-intestinal immune responses upon multi-drug resistant Pseudomonas aeruginosa association of IL10−/− mice with chronic colitis

Fig. 1

Intestinal colonization properties of multi-drug resistant P. aeruginosa following peroral association of IL10−/− mice lacking TLR4. Conventionally colonized a IL10 deficient (IL10−/−; closed circles) and b TLR4 deficient IL10−/− mice (TLR4−/− × IL10−/−; closed triangles) were perorally challenged with a clinical multi-drug resistant P. aeruginosa strain at day (d) 0. Intestinal colonization densities were determined in fecal samples until d14 postinfection by culture and expressed as colony forming units per gram (CFU/g). Numbers of mice harboring P. aeruginosa out of the total number of analyzed mice (in parentheses), medians (black bars) and significance levels (p values) determined by Mann–Whitney U test and Wilcoxon Test are indicated. Asterisks illustrate significant differences between genotypes at defined time points (*p < 0.05; **p < 0.01; ***p < 0.001); #p < 0.001 (d1 versus all other time points); §p < 0.001 (d0 versus all other time points). p values in numbers indicate differences between mice of identical genotype at distinct time points as shown by the horizontal bar underneath. Data shown were pooled from at least three independent experiments

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