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Fig. 2 | Gut Pathogens

Fig. 2

From: Toll-like receptor-4 differentially mediates intestinal and extra-intestinal immune responses upon multi-drug resistant Pseudomonas aeruginosa association of IL10−/− mice with chronic colitis

Fig. 2

Multi-drug resistant P. aeruginosa loads in the gastrointestinal tract following peroral association of IL10−/− mice lacking TLR4. Conventionally colonized IL10 deficient (WT IL10−/−; closed circles) and TLR4 deficient IL10−/− mice (TLR4−/− × IL10−/−; closed triangles) were perorally challenged with a clinical multi-drug resistant P. aeruginosa strain at day (d) 0. At necropsy (i.e. d14 postinfection), P. aeruginosa loads were quantitatively assessed in gastrointestinal luminal samples derived from stomach, duodenum, ileum und colon by culture and expressed as colony forming units per gram (CFU/g). Numbers of mice harboring P. aeruginosa out of the total number of analyzed mice (in parentheses), medians (black bars) and significance levels (p values) determined by Mann–Whitney U test are indicated. Data were pooled from at least three independent experiments

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