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Fig. 3 | Gut Pathogens

Fig. 3

From: Toll-like receptor-4 differentially mediates intestinal and extra-intestinal immune responses upon multi-drug resistant Pseudomonas aeruginosa association of IL10−/− mice with chronic colitis

Fig. 3

Intestinal microbiota composition before peroral association of IL10−/− mice lacking TLR4 with multi-drug resistant P. aeruginosa. Immediately before peroral challenge with a clinical multi-drug resistant P. aeruginosa strain at day (d) 0, a comprehensive survey of the intestinal microbiota composition was performed on fecal samples derived from conventionally colonized IL10 deficient (WT IL10−/−; open circles) and TLR4 deficient IL10−/− mice (TLR4−/− × IL10−/−; open triangles), and the following intestinal commensal bacteria were assessed by culture (expressed as colony forming units per gram, CFU/g): Enterobacteria (EB), enterococci (EC), lactic acid bacteria (LAB), Bacteroides/Prevotella spp. (B/P), Clostridium/Eubacterium spp. (C/E) and total bacterial loads (TL). Numbers of mice harboring the respective commensal intestinal bacteria out of the total number of analyzed mice (in parentheses), medians (black bars) and significance levels (p values) determined by Mann–Whitney U test are indicated. Data were pooled from at least three independent experiments

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Gut Pathogens

ISSN: 1757-4749