From: Gut colonization with vancomycin-resistant Enterococcus and risk for subsequent enteric infection
Variable | Total (n = 761) | No VRE (n = 630, 82.8%) | VRE (n = 131, 17.2%) | p value |
---|---|---|---|---|
Sex | ||||
Male | 387 (51%) | 330 (52%) | 57 (43.5%) | |
Female | 374 (49%) | 300 (48%) | 74 (56.5%) | 0.07 |
Race | ||||
Asian | 31 (4.1%) | 27 (4.3%) | 4 (3.1%) | |
Black | 89 (11%) | 77 (12%) | 12 (9.2%) | |
White | 286 (38%) | 231 (37%) | 55 (42.0%) | |
Other/unknown | 355 (47%) | 295 (47%) | 60 (45.8%) | 0.55 |
Ethnicity | ||||
Hispanic | 128 (17%) | 114 (18%) | 14 (10.7%) | |
Non-hispanic | 280 (37%) | 220 (35%) | 60 (45.8%) | |
Unknown | 353 (46%) | 296 (47%) | 57 (43.5%) | 0.03 |
Age group | ||||
18–29 | 58 (7.6%) | 45 (7.1%) | 13 (9.9%) | |
30–49 | 137 (18%) | 115 (18%) | 22 (16.8%) | |
50–69 | 366 (48%) | 304 (48%) | 62 (47.3%) | |
> 70 | 200 (26%) | 166 (26%) | 34 (26.0%) | 0.74 |
Residential zip code | ||||
New York city | 414 (54%) | 342 (54%) | 72 (55.0%) | |
Tristate area | 328 (43%) | 273 (43%) | 55 (42.0%) | |
Other | 19 (2.5%) | 15 (2.4%) | 4 (3.1%) | 0.88 |
Laboratory values at VRE testing (median, IQR) | ||||
Creatinine (mg/dL) | 1.1 (0.8–2.1) | 1.1 (0.7–1.1) | 1.03 (0.8–2.0) | 0.58 |
Albumin (g/dL) | 2.8 (2.4–3.2) | 2.8 (2.4–3.2) | 2.7 (2.3–3.1) | 0.11 |
White blood cell count (cells × 103/µL) | 10 (6.5–14) | 10 (6.5–14) | 9.6 (6.3–14) | 0.74 |
Hematocrit (%) | 33 (32–34) | 33 (32–34) | 33 (31–34) | 0.19 |
Platelets (× 103/µL) | 138 (135–141) | 138 (135–141) | 137 (135–141) | 0.11 |
Surgery after VRE test | 246 (32%) | 209 (33%) | 37 (28%) | 0.27 |
Mechanical ventilation after VRE test | 450 (59%) | 371 (59%) | 79 (60%) | 0.76 |
Immunosuppression exposure after VRE test | 430 (57%) | 348 (55%) | 82 (63%) | 0.12 |
Antibiotic exposure after VRE test | ||||
Any antibiotic | 719 (95%) | 483 (77%) | 131 (100%) | < 0.01 |
Vancomycin IV | 571 (75%) | 467 (74%) | 104 (79%) | 0.21 |
VRE-targeted therapy | 15 (2.6%) | 13 (2.7%) | 2 (1.9%) | 0.64 |
LOS (days; median, IQR) | ||||
Hospital LOS | 15 (8–31) | 14 (7–29) | 19 (10–44) | < 0.01 |
Intensive care unit LOS | 4 (2–8) | 4 (2–8) | 5 (3–9) | 0.01 |
In-hospital mortality | 52 (6.8%) | 36 (5.7%) | 16 (12%) | < 0.01 |