Table 2 DP-HMGS exhibited uniformly high sensitivity of DP detection compared to the sequencing method
Pathogens | HMGS | Sequencing | Sensitivity | Specificity | PPV | NPV | Accuracy | |
|---|---|---|---|---|---|---|---|---|
+ | − | |||||||
Vibrio | + | 39 | 1 | 0.975 | 0.998 | 0.975 | 0.998 | 0.997 |
− | 1 | 572 | ||||||
S. typhimurium | + | 41 | 1 | 1.000 | 0.998 | 0.976 | 1.000 | 0.998 |
− | 0 | 571 | ||||||
S. enteritis | + | 4 | 2 | 0.667 | 0.997 | 0.667 | 0.997 | 0.993 |
− | 2 | 605 | ||||||
Shigella | + | 9 | 1 | 1.000 | 0.998 | 0.900 | 1.000 | 0.998 |
− | 0 | 603 | ||||||
C. difficile | + | 28 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
− | 0 | 585 | ||||||
C. jejuni | + | 44 | 0 | 0.978 | 1.000 | 1.000 | 0.998 | 0.998 |
− | 1 | 568 | ||||||
Y. enterocolitica | + | 1 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
− | 0 | 612 | ||||||
EPEC | + | 151 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
− | 0 | 462 | ||||||
ETEC | + | 29 | 2 | 1.000 | 0.997 | 0.935 | 1.000 | 0.997 |
− | 0 | 582 | ||||||
EAEC | + | 27 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
− | 0 | 586 | ||||||
EIEC | + | 8 | 1 | 1.000 | 0.998 | 0.889 | 1.000 | 0.998 |
− | 0 | 604 | ||||||
EHEC | + | 4 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
− | 0 | 609 | ||||||
E. coli O157 | + | 6 | 2 | 1.000 | 0.997 | 0.750 | 1.000 | 0.997 |
− | 0 | 605 | ||||||
Norovirus | + | 31 | 7 | 1.000 | 0.988 | 0.816 | 1.000 | 0.982 |
− | 0 | 575 | ||||||
Rotavirus | + | 55 | 2 | 1.000 | 0.996 | 0.964 | 1.000 | 0.990 |
− | 0 | 556 | ||||||
Adenovirus | + | 9 | 3 | 1.000 | 0.995 | 0.750 | 1.000 | 0.993 |
− | 0 | 601 | ||||||
Astrovirus | + | 4 | 0 | 1.000 | 1.000 | 1.000 | 1.000 | 0.997 |
− | 0 | 609 | ||||||