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Table 3 DP-HMGS analysis revealed significant effects of age and gender on the frequencies of common DP infections

From: Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai

Pathogens Positive numbers (n[%]) (n = 613) Age (n[%]) P value Gender (n[%]) P value
0–19 (n = 117) 20–39 (n = 213) 40–59 (n = 134) 60–79 (n = 138) ≥ 80 (n = 11) Male (n = 319) Female (n = 294)
Bacteria 401 (65.4) 41 (35.0) 170 (79.8) 92 (68.7) 91 (65.9) 7 (63.6) 0.000 215 (67.4) 186 (63.3) 0.282
Vibrio 40 (6.5) 1 (0.9) 18 (8.5) 13 (9.7) 7 (5.1) 1 (9.1) 0.011 24 (7.5) 16 (5.4) 0.297
S. typhimurium 42 (6.9) 0 (0.0) 19 (8.9) 8 (6.0) 14 (10.1) 1 (9.1) 0.001 23 (7.2) 19 (6.5) 0.714
S. enteritidis 6 (1.0) 1 (0.9) 3 (1.4) 2 (1.5) 0 (0.0) 0 (0.0) 0.636 2 (0.6) 4 (1.4) 0.357
Shigella 10 (1.6) 1 (0.9) 4 (1.9) 3 (2.2) 1 (0.7) 1 (9.1) 0.266 1 (0.3) 9 (3.1) 0.009
C. difficile 28 (4.6) 12 (10.3) 7 (3.3) 6 (4.5) 3 (2.2) 0 (0.0) 0.042 17 (5.3) 11 (3.7) 0.347
C. jejuni 44 (7.2) 6 (5.1) 22 (10.3) 12 (9.0) 4 (2.9) 0 (0.0) 0.060 21 (6.6) 23 (7.8) 0.552
Y. enterocolitica 1 (0.2) 0 (0) 1 (0.5) 0 (0) 0 (0) 0 (0) 1.000 1 (0.3) 0 (0) 0.337
EPEC 151 (24.6) 13 (11.1) 64 (30.0) 31 (23.1) 41 (29.7) 2 (18.2) 0.020 85 (26.6) 66 (22.4) 0.228
ETEC 31 (5.1) 0 (0) 13 (6.1) 7 (7.5) 10 (7.2) 1 (9.1) 0.014 16 (5.0) 15 (5.1) 0.961
EAEC 27 (4.4) 3 (2.6) 10 (4.7) 6 (4.5) 8 (5.8) 0 (0.0) 0.794 17 (5.3) 10 (3.4) 0.245
EIEC 9 (1.5) 1 (0.9) 3 (1.4) 3 (2.2) 1 (0.7) 1 (9.1) 0.235 1 (0.3) 8 (2.7) 0.017
EHEC 4 (0.7) 2 (1.7) 2 (0.9) 0 (0) 0 (0) 0 (0) 0.311 3 (0.9) 1 (0.3) 0.625
E. coli O157 8 (1.3) 1 (0.9) 4 (1.9) 1 (0.7) 2 (1.4) 0 (0) 0.883 4 (1.3) 4 (1.4) 1.000
Viruses 111 (18.1) 63 (53.9) 22 (10.3) 17 (12.7) 8 (5.8) 1 (9.1) 0.000 56 (17.6) 55 (18.7) 0.711
Norovirus 38 (6.2) 6 (5.1) 17 (8.0) 9 (6.7) 5 (3.6) 1 (9.1) 0.426 20 (6.3) 18 (6.1) 0.940
Rotavirus 57 (9.3) 48 (41.0) 1 (0.5) 5 (3.7) 3 (2.2) 0 (0) 0.000 31 (9.7) 26 (8.8) 0.710
Adenovirus 12 (2.0) 7 (6.0) 3 (1.4) 2 (1.5) 0 (0) 0 (0) 0.019 3 (0.9) 9 (3.1) 0.079
Astrovirus 4 (0.7) 2 (1.7) 1 (0.5) 1 (0.7) 0 (0) 0 (0) 0.377 2 (0.6) 2 (0.7) 1.000
Total 512 (83.5) 104 (88.9) 192 (90.1) 109 (81.3) 99 (71.7) 8 (72.7) 0.000 271 (85.0) 241 (82.0) 0.320
  1. The outcomes of positive DP-HMGS detection were categorized into appropriate age and gender groups. Notably, incidences of some DPs exhibited significant age and gender dependence