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Table 3 DP-HMGS analysis revealed significant effects of age and gender on the frequencies of common DP infections

From: Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai

Pathogens

Positive numbers (n[%]) (n = 613)

Age (n[%])

P value

Gender (n[%])

P value

0–19 (n = 117)

20–39 (n = 213)

40–59 (n = 134)

60–79 (n = 138)

≥ 80 (n = 11)

Male (n = 319)

Female (n = 294)

Bacteria

401 (65.4)

41 (35.0)

170 (79.8)

92 (68.7)

91 (65.9)

7 (63.6)

0.000

215 (67.4)

186 (63.3)

0.282

Vibrio

40 (6.5)

1 (0.9)

18 (8.5)

13 (9.7)

7 (5.1)

1 (9.1)

0.011

24 (7.5)

16 (5.4)

0.297

S. typhimurium

42 (6.9)

0 (0.0)

19 (8.9)

8 (6.0)

14 (10.1)

1 (9.1)

0.001

23 (7.2)

19 (6.5)

0.714

S. enteritidis

6 (1.0)

1 (0.9)

3 (1.4)

2 (1.5)

0 (0.0)

0 (0.0)

0.636

2 (0.6)

4 (1.4)

0.357

Shigella

10 (1.6)

1 (0.9)

4 (1.9)

3 (2.2)

1 (0.7)

1 (9.1)

0.266

1 (0.3)

9 (3.1)

0.009

C. difficile

28 (4.6)

12 (10.3)

7 (3.3)

6 (4.5)

3 (2.2)

0 (0.0)

0.042

17 (5.3)

11 (3.7)

0.347

C. jejuni

44 (7.2)

6 (5.1)

22 (10.3)

12 (9.0)

4 (2.9)

0 (0.0)

0.060

21 (6.6)

23 (7.8)

0.552

Y. enterocolitica

1 (0.2)

0 (0)

1 (0.5)

0 (0)

0 (0)

0 (0)

1.000

1 (0.3)

0 (0)

0.337

EPEC

151 (24.6)

13 (11.1)

64 (30.0)

31 (23.1)

41 (29.7)

2 (18.2)

0.020

85 (26.6)

66 (22.4)

0.228

ETEC

31 (5.1)

0 (0)

13 (6.1)

7 (7.5)

10 (7.2)

1 (9.1)

0.014

16 (5.0)

15 (5.1)

0.961

EAEC

27 (4.4)

3 (2.6)

10 (4.7)

6 (4.5)

8 (5.8)

0 (0.0)

0.794

17 (5.3)

10 (3.4)

0.245

EIEC

9 (1.5)

1 (0.9)

3 (1.4)

3 (2.2)

1 (0.7)

1 (9.1)

0.235

1 (0.3)

8 (2.7)

0.017

EHEC

4 (0.7)

2 (1.7)

2 (0.9)

0 (0)

0 (0)

0 (0)

0.311

3 (0.9)

1 (0.3)

0.625

E. coli O157

8 (1.3)

1 (0.9)

4 (1.9)

1 (0.7)

2 (1.4)

0 (0)

0.883

4 (1.3)

4 (1.4)

1.000

Viruses

111 (18.1)

63 (53.9)

22 (10.3)

17 (12.7)

8 (5.8)

1 (9.1)

0.000

56 (17.6)

55 (18.7)

0.711

Norovirus

38 (6.2)

6 (5.1)

17 (8.0)

9 (6.7)

5 (3.6)

1 (9.1)

0.426

20 (6.3)

18 (6.1)

0.940

Rotavirus

57 (9.3)

48 (41.0)

1 (0.5)

5 (3.7)

3 (2.2)

0 (0)

0.000

31 (9.7)

26 (8.8)

0.710

Adenovirus

12 (2.0)

7 (6.0)

3 (1.4)

2 (1.5)

0 (0)

0 (0)

0.019

3 (0.9)

9 (3.1)

0.079

Astrovirus

4 (0.7)

2 (1.7)

1 (0.5)

1 (0.7)

0 (0)

0 (0)

0.377

2 (0.6)

2 (0.7)

1.000

Total

512 (83.5)

104 (88.9)

192 (90.1)

109 (81.3)

99 (71.7)

8 (72.7)

0.000

271 (85.0)

241 (82.0)

0.320

  1. The outcomes of positive DP-HMGS detection were categorized into appropriate age and gender groups. Notably, incidences of some DPs exhibited significant age and gender dependence