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Table 3 Predicting the impact of novel amino acid substitutions on the biological function of proteins using PROVEAN tool

From: Prevalence and molecular determinants of colistin resistance among commensal Enterobacteriaceae isolated from poultry in northwest of Iran

Protein

Variant

PROVEAN score

Prediction (cutoff = − 2.5)

Isolatesa

PmrB

T93N

− 3.38

Deleterious

ColR

CrrB

K325R

− 0.134

Neutral

ColR, ColS

CrrB

F303S

− 7.99

Deleterious

ColR

CrrB

I27V

− 0.055

Neutral

ColR

CrrB

T150R

− 5.99

Deleterious

ColR

CrrA

A83V

− 3.87

Deleterious

ColR

  1. aIsolates in which the specific amino acid substitution has been identified